iPTMnet Report for P17405 (SMPD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17405 / ASM_HUMAN
Protein Name Sphingomyelin phosphodiesterase precursor
Gene Name Name: SMPD1
Synonyms:ASM;
Organism Homo sapiens (Human)

PRO ID PR:P17405
DAG View
PRO Name sphingomyelin phosphodiesterase (human)
Definition A sphingomyelin phosphodiesterase that is encoded in the genome of human.
Short Label hSMPD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17405 (SMPD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
N88 N-Glycosylation GlyGen   UniProt 29671580, 27349982, 9030779
N177 N-Glycosylation GlyGen   UniProt 27349982, 9030779
S233 Phosphorylation PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
N337 N-Glycosylation GlyGen   UniProt 27349982, 9030779
N397 N-Glycosylation GlyGen   UniProt 27349982, 9030779
N505 N-Glycosylation GlyGen   UniProt 27349982
S510 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus   Signor   UniProt 17303575
N522 N-Glycosylation GlyGen   UniProt 27349982, 9030779
Site PTM Type PTM Enzyme Score Source PMID
N88 N-Glycosylation PRO 29671580
S116 Phosphorylation HPRD 17322306
S510 Phosphorylation PRO 17303575


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045691 (hSMPD1/Phos:1) pS510 PRO 17303575


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N505 K505 Biomuta DOID:1324 / lung cancer [ cosmic ]
S510 P510 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S510 F510 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]