Protein Information

Cytoscape View


UniProt AC / UniProt ID P17174 / AATC_HUMAN
Protein Name Aspartate aminotransferase, cytoplasmic
Gene Name Name: GOT1
Organism Homo sapiens (Human)

PRO ID PR:P17174
DAG View
PRO Name aspartate aminotransferase, cytoplasmic (human)
Definition An aspartate aminotransferase, cytoplasmic that is encoded in the genome of human.
Short Label hGOT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17174 (GOT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K33 Ubiquitination PhosphoSitePlus
Y41 Phosphorylation PhosphoSitePlus
C46 S-Nitrosylation dbSNO 19483679, 26338901
K55 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
Y71 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K97 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
T140 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
K166 Acetylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
Y226 Phosphorylation PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
R330 Methylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
Y373 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
Y381 Phosphorylation PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
Y400 Phosphorylation PhosphoSitePlus
T403 Phosphorylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y71 Phosphorylation HPRD 18083107
T333 Phosphorylation HPRD 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S66 R66 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K166 N166 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S211 Y211 Biomuta DOID:3571 / liver cancer [ icgc ]
S385 G385 Biomuta DOID:10534 / stomach cancer [ tcga ]
S391 N391 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
Y400 * Biomuta DOID:3571 / liver cancer [ icgc ]
K411 Q411 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]