iPTMnet Report for P16949 (STMN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16949 / STMN1_HUMAN
Protein Name Stathmin
Gene Name Name: STMN1
Synonyms:C1orf215,LAP18,OP18;
Organism Homo sapiens (Human)

PRO ID PR:P16949
DAG View
PRO Name stathmin (human)
Definition A stathmin that is encoded in the genome of human.
Short Label hSTMN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16949 (STMN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 1737801, 19413330, 22814378, ...22223895
S3 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus   UniProt 23186163
K9 Acetylation PhosphoSitePlus   UniProt 19608861
K9 Ubiquitination PhosphoSitePlus
R14 Methylation PhosphoSitePlus
S16 Phosphorylation Q13153 (PAK1) , Q16566 (CAMK4) , Q13554 (CAMK2B) , P17612 (PRKACA) , Q9UQM7 (CAMK2A) IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9154845, 16964243, 11015208, ...19359244, 7925472, 21768358, 8245003, 29034341, 17389683, 26654769, 8125092, 11058583, 21406692, 23186163, 9425161, 28534969, 23383112, 14645234, 24152729, 8002936, 16554300, 9271428, 10913145, 30784271, 19690332, 27041561, 26356819, 16982419, 26466335, 18220336, 21949786, 9788875, 20927383, 33839152, 9686569, 12111843, 25320307, 33037191, 28460485, 7775478, 17287340, 17081983, 20110360, 25285524, 8376365, 9369201, 31546234, 26087399, 26317901, 20068231, 17924679
S25 Phosphorylation P53778 (MAPK12) , P45983 (MAPK8) , P24941 (CDK2) , P27361 (MAPK3) , Q15759 (MAPK11) , P05771 (PRKCB) , P45984 (MAPK9) , O15264 (MAPK13) , P06493 (CDK1) , Q16539 (MAPK14) , P53779 (MAPK10) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9154845, 20630875, 16964243, ...22028470, 19359244, 26881937, 7925472, 17693683, 8245003, 7982983, 1737801, 7851413, 7637391, 12111843, 21406692, 16925597, 9712920, 7775478, 20927383, 23186163, 23230143, 18220336, 8002936, 16554300, 9271428, 19690332, 19033656, 8125092, 8325880, 25063586, 18847512, 19162178, 33839152, 9686569, 16110469, 9731215, 25375189, 18234856, 16083285, 17287340, 17081983, 16094384, 33004792, 20110360, 25285524, 9369201, 31546234, 26087399, 27130664, 30628717, 8314790, 28259950, 20068231, 17924679
R27 Methylation PhosphoSitePlus
S28 O-Glycosylation GlyGen 20305658, 33214551, 34019948, ...31373491, 28657654
S28 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K29 Acetylation PhosphoSitePlus
K29 Methylation PhosphoSitePlus   UniProt 24129315
K29 Ubiquitination PhosphoSitePlus
S31 O-Glycosylation GlyGen 20305658, 33214551, 34019948, ...31373491, 28657654
S31 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S38 Phosphorylation Q00535 (CDK5) , O15264 (MAPK13) , P45983 (MAPK8) , Q8TAS1 (UHMK1) , Q13153 (PAK1) , P05771 (PRKCB) , P06493 (CDK1) , P28482 (MAPK1) , P53779 (MAPK10) , P24941 (CDK2) , P45984 (MAPK9) , P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20630875, 16964243, 22028470, ...19359244, 28534969, 33839152, 23538402, 8245003, 7982983, 1737801, 7851413, 7637391, 17693683, 16925597, 12111843, 26654769, 8125092, 21406692, 23186163, 9425161, 23230143, 18234856, 24066165, 19033656, 16554300, 24275569, 7925472, 10913145, 9712920, 19690332, 28499923, 8325881, 8325880, 9271428, 25063586, 18847512, 26466335, 20927383, 19162178, 9686569, 16110469, 11870780, 9731215, 24302736, 32793885, 7775478, 17287340, 17081983, 20110360, 25285524, 18669648, 9369201, 31546234, 26087399, 27130664, 8314790, 20068231, 17924679
K41 Ubiquitination PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
S63 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11015208, 19359244, 7925472, ...8125092, 7775478, 21406692, 23186163, 14645234, 24152729, 8002936, 16554300, 9271428, 10913145, 9425161, 17001604, 33839152, 9686569, 8376365, 24302736, 33037191, 11415983, 17287340, 17081983, 20110360, 31546234, 25198505, 30628717, 28259950, 20068231, 17924679
K70 Acetylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
K95 Acetylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K100 Acetylation PhosphoSitePlus   UniProt 19608861
K100 Ubiquitination PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K109 Acetylation PhosphoSitePlus
K119 Acetylation PhosphoSitePlus   UniProt 19608861
K119 Ubiquitination PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
R134 Methylation PhosphoSitePlus
K137 Acetylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
T146 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation P68400 (CSNK2A1) , P17612 (PRKACA) HPRD 19413330, 17287340, 16964243, ...8002936, 18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 8376365, 17693683, 17924679, 19415658, 20068231, 18212344
S25 Phosphorylation P06493 (CDK1) , P27361 (MAPK3) HPRD 11135364, 16964243, 18707149, ...17693683, 8125092, 18212344, 20230923, 18452278, 19413330, 8325880, 18767875, 20058876, 19651622, 8376365, 18491316, 17287340, 19664994, 19664995, 18669648, 19415658, 20068231, 17924679
S28 Phosphorylation HPRD 17287340
S31 Phosphorylation HPRD 20068231
S38 Phosphorylation P06493 (CDK1) HPRD 19413330, 8125092, 18578522, ...18491316, 17287340, 16964243, 20230923, 18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 8376365, 20058876, 17693683, 16427064, 17924679, 19415658, 20068231, 18212344
S46 Phosphorylation HPRD 18510355, 19651622, 19664994
S63 Phosphorylation P68400 (CSNK2A1) , P17612 (PRKACA) HPRD 17287340, 18212344, 8002936, ...18767875, 19651622, 18669648, 8376365, 20068231, 17924679
T102 Phosphorylation HPRD 19664994
T146 Phosphorylation HPRD 17287340


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P16949 (STMN1) S16 Q13555 (CAMK2G) inhibited_association eFIP 26317901
Phosphorylation P46527 (CDKN1B) T198 P16949 (STMN1) unknown eFIP 30992462


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 G2 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R14 C14 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S28 P28 Biomuta DOID:1319 / brain cancer [ icgc ]
K29 I29 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S31 Y31 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S31 P31 Biomuta DOID:1319 / brain cancer [ cosmic ]
S63 P63 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S63 F63 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R134 Q134 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T146 N146 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]