Protein Information

Cytoscape View


UniProt AC / UniProt ID P16885 / PLCG2_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Gene Name Name: PLCG2
Organism Homo sapiens (Human)

PRO ID PR:P16885
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 that is encoded in the genome of human.
Short Label hPLCG2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16885 (PLCG2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S160 Phosphorylation PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
T276 Phosphorylation HPRD   PhosphoSitePlus 19664994
Y371 Phosphorylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
Y482 Phosphorylation PhosphoSitePlus
Y495 Phosphorylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
Y647 Phosphorylation PhosphoSitePlus
S677 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
Y680 Phosphorylation PhosphoSitePlus
T683 Phosphorylation PhosphoSitePlus
Y720 Phosphorylation PhosphoSitePlus
Y733 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
Y743 Phosphorylation P07948 (LYN) , P06241 (FYN) , P06239 (LCK) phospho.ELM   PhosphoSitePlus 12181444
Y753 Phosphorylation P08631 (HCK) , P12931 (SRC) , P42680 (TEC) , P06241 (FYN) , P06239 (LCK) , Q06187 (BTK) , P07948 (LYN) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15509800, 15184383, 7682059, ...11606584, 20158382, 15144186, 12181444, 19690332, 14656219, 10498607, 15879121, 11507089
S756 Phosphorylation PhosphoSitePlus
Y759 Phosphorylation Q06187 (BTK) , P43405 (SYK) , P06241 (FYN) , P12931 (SRC) , P42680 (TEC) , P08631 (HCK) , P06239 (LCK) , P07948 (LYN) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19901323, 15509800, 15184383, ...7682059, 11606584, 12181444, 27045816, 19690332, 14656219, 10498607, 11507089, 20158382, 16497976
S763 Phosphorylation PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
Y778 Phosphorylation PhosphoSitePlus
Y780 Phosphorylation PhosphoSitePlus
S789 Phosphorylation PhosphoSitePlus
Y811 Phosphorylation PhosphoSitePlus
Y818 Phosphorylation PhosphoSitePlus
T857 Phosphorylation PhosphoSitePlus
Y858 Phosphorylation PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
Y936 Phosphorylation PhosphoSitePlus
S941 Phosphorylation PhosphoSitePlus
S957 Phosphorylation PhosphoSitePlus
K962 Ubiquitination PhosphoSitePlus
S965 Phosphorylation PhosphoSitePlus
K980 Ubiquitination PhosphoSitePlus
S994 Phosphorylation PhosphoSitePlus
S1007 Phosphorylation PhosphoSitePlus
T1016 Phosphorylation PhosphoSitePlus
Y1020 Phosphorylation PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus
T1034 Phosphorylation PhosphoSitePlus
Y1036 Phosphorylation PhosphoSitePlus
T1045 Phosphorylation PhosphoSitePlus
K1047 Ubiquitination PhosphoSitePlus
Y1048 Phosphorylation PhosphoSitePlus
T1062 Phosphorylation PhosphoSitePlus
T1064 Phosphorylation PhosphoSitePlus
Y1137 Phosphorylation PhosphoSitePlus
S1164 Phosphorylation PhosphoSitePlus
Y1197 Phosphorylation Q06187 (BTK) , P06239 (LCK) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 10498607, 15184383, 11507089
Y1217 Phosphorylation Q06187 (BTK) , P06239 (LCK) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19901323, 15509800, 15184383, ...10498607, 17239630, 19690332, 11507089, 16497976
T1219 Phosphorylation PhosphoSitePlus
K1233 Ubiquitination PhosphoSitePlus
S1236 Phosphorylation PhosphoSitePlus
Y1245 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 11971963, 15144186
K1248 Ubiquitination PhosphoSitePlus
S1259 Phosphorylation PhosphoSitePlus
S1261 Phosphorylation PhosphoSitePlus
K1262 Ubiquitination PhosphoSitePlus
Y1264 Phosphorylation PhosphoSitePlus
S1265 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048806 (hPLCG2/Phos:1) pY753,pY759 PRO
PR:000048807 (hPLCG2/Phos:2) pY753,pY759,pY1197,pY1217 PRO
PR:000048808 (hPLCG2/Phos:3) pY753,pY759,pY1217 PRO
PR:000048809 (hPLCG2/PhosRes+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y680 F680 Biomuta DOID:1324 / lung cancer [ cosmic ]
S763 N763 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S941 R941 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S957 F957 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K962 N962 Biomuta DOID:3571 / liver cancer [ icgc ]
T1016 M1016 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ icgc, tcga ]
T1034 M1034 Biomuta DOID:1909 / melanoma [ tcga ]
Y1036 D1036 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
T1062 S1062 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S1164 F1164 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:1909 / melanoma [ tcga ]
Y1197 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S1236 N1236 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S1259 I1259 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1261 I1261 Biomuta DOID:363 / uterine cancer [ tcga ]
Y1264 * Biomuta DOID:9256 / colorectal cancer [ tcga ]