iPTMnet Report for P16615 (ATP2A2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16615 / AT2A2_HUMAN
Protein Name Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Gene Name Name: ATP2A2
Synonyms:ATP2B;
Organism Homo sapiens (Human)

PRO ID PR:P16615
DAG View
PRO Name sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (human)
Definition A sarcoplasmic/endoplasmic reticulum calcium ATPase 2 that is encoded in the genome of human.
Short Label hATP2A2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16615 (ATP2A2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K30 Ubiquitination PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K33 Acetylation PhosphoSitePlus
S38 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 9202841, 7929371
S38 Phosphorylation Q9UQM7 (CAMK2A) Signor 7929371
K120 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
R164 Methylation PhosphoSitePlus
S167 Phosphorylation RLIMS-P 7929371
K169 Ubiquitination PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
K218 Acetylation PhosphoSitePlus
T226 Phosphorylation PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
Y294 Phosphorylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
C364 S-Nitrosylation dbSNO 26338901
K400 Ubiquitination PhosphoSitePlus
Y427 Phosphorylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
T441 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K464 Acetylation PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K476 Acetylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K480 Sumoylation PhosphoSitePlus
K481 Acetylation PhosphoSitePlus
K481 Ubiquitination PhosphoSitePlus
T484 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
K492 Acetylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
Y497 Phosphorylation PhosphoSitePlus
C498 S-Nitrosylation dbSNO 26338901, 22126794, 24105792
T499 Phosphorylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K514 Acetylation PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
R523 Methylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
T532 Phosphorylation PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K543 Ubiquitination PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
R549 Methylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
C560 S-Nitrosylation dbSNO 20140087
S580 Phosphorylation PhosphoSitePlus   UniProt 24275569
K585 Sumoylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
T624 Phosphorylation PhosphoSitePlus
K628 Ubiquitination PhosphoSitePlus
C635 Methylation IEDB 31844290
T648 Phosphorylation PhosphoSitePlus
S649 Phosphorylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
S663 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 17081983, ...15302935, 14722118, 18669648, 24275569, 19690332
K683 Ubiquitination PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
K712 Ubiquitination PhosphoSitePlus
S721 Phosphorylation PhosphoSitePlus
T723 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus
T741 Phosphorylation PhosphoSitePlus
K757 Acetylation PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
S829 Phosphorylation PhosphoSitePlus
Y836 Phosphorylation PhosphoSitePlus
Y867 Phosphorylation PhosphoSitePlus
S973 Phosphorylation PhosphoSitePlus
T982 Phosphorylation PhosphoSitePlus
Y990 Phosphorylation PhosphoSitePlus
K995 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation HPRD 7929371
S38 Phosphorylation Q9UQM7 (CAMK2A) HPRD 7929371
S178 Phosphorylation HPRD 20068231
S184 Phosphorylation HPRD 20068231
S663 Phosphorylation HPRD 18691976, 18578522, 20058876, ...19664994, 18452278, 19651622, 15302935, 18669648, 20166139, 19415658, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S38 Phosphorylation HPRD 7929371
S38 Phosphorylation Q9UQM7 (CAMK2A) HPRD 7929371
S178 Phosphorylation HPRD 20068231
S184 Phosphorylation HPRD 20068231
S663 Phosphorylation HPRD 18691976, 18578522, 20058876, ...19664994, 18452278, 19651622, 15302935, 18669648, 20166139, 19415658, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K158 E158 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S167 F167 Biomuta DOID:4159 / skin cancer [ cosmic ]
K169 T169 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S178 L178 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
T242 I242 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S338 F338 Biomuta [ cosmic ]
K481 R481 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K481 N481 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
C498 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T499 A499 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K510 N510 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K510 T510 Biomuta DOID:1324 / lung cancer [ cosmic ]
S531 R531 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S538 Y538 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K543 T543 Biomuta DOID:363 / uterine cancer [ cosmic ]
K543 N543 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S553 R553 Biomuta DOID:1324 / lung cancer [ cosmic ]
K683 M683 Biomuta DOID:3571 / liver cancer [ cosmic ]
S730 T730 Biomuta DOID:1324 / lung cancer [ cosmic ]
S730 Y730 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S730 C730 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S973 F973 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T982 M982 Biomuta [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]