Protein Information

Cytoscape View


UniProt AC / UniProt ID P16471 / PRLR_HUMAN
Protein Name Prolactin receptor precursor
Gene Name Name: PRLR
Organism Homo sapiens (Human)

PRO ID PR:P16471
DAG View
PRO Name prolactin receptor (human)
Definition A prolactin receptor that is encoded in the genome of human.
Short Label hPRLR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16471 (PRLR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S195 Phosphorylation PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
S349 Phosphorylation P49841 (GSK3B) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P 15082796, 22606260, 18252943, ...18316598, 19276348, 16278670
S356 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
T391 Phosphorylation RLIMS-P 12819209
T415 Phosphorylation phospho.ELM   PhosphoSitePlus 12819209
Y509 Phosphorylation PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
Y611 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 7537382
Site PTM Type PTM Enzyme Score Source PMID
T415 Phosphorylation HPRD 12819209
Y611 Phosphorylation HPRD 9626554
Site PTM Type PTM Enzyme Score Source PMID
K357 Methylation PhosphoSitePlus
K369 Methylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048928 (hPRLR/SigPep-/Phos:1) pY611 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S195 I195 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S356 R356 Biomuta DOID:1909 / melanoma [ icgc, tcga ] DOID:3571 / liver cancer [ icgc ]
S356 N356 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:1909 / melanoma [ tcga ]
T391 N391 Biomuta DOID:1324 / lung cancer [ cosmic ]
T415 A415 Biomuta DOID:363 / uterine cancer [ tcga ]
S522 L522 Biomuta DOID:1909 / melanoma [ icgc, tcga ]