iPTMnet Report for P16422 (EPCAM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16422 / EPCAM_HUMAN
Protein Name Epithelial cell adhesion molecule precursor
Gene Name Name: EPCAM
Synonyms:GA733-2,M1S2,M4S1,MIC18,TACSTD1,TROP1;
Organism Homo sapiens (Human)

PRO ID PR:P16422
DAG View
PRO Name epithelial cell adhesion molecule (human)
Definition An epithelial cell adhesion molecule that is encoded in the genome of human.
Short Label hEPCAM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16422 (EPCAM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C38 Methylation IEDB 31844290
N74 N-Glycosylation GlyGen   UniProt 18508581, 29741879, 11080501
N111 N-Glycosylation GlyGen   UniProt 18508581, 29741879, 11080501
K168 Ubiquitination PhosphoSitePlus
T171 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T172 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
N198 N-Glycosylation GlyGen   UniProt 18508581, 29741879, 19159218
Y214 Phosphorylation PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus   RLIMS-P 33324790
K299 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N74 N-Glycosylation PRO 29741879


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C38 Y38 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
N111 K111 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K168 N168 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T172 M172 Biomuta DOID:11615 / penile cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
N198 H198 Biomuta DOID:363 / uterine cancer [ icgc ]