Protein Information

Cytoscape View


UniProt AC / UniProt ID P16403 / H12_HUMAN
Protein Name Histone H1.2
Gene Name Name: HIST1H1C
Synonyms:H1F2;
Organism Homo sapiens (Human)

PRO ID PR:P16403
DAG View
PRO Name histone H1.2 (human)
Definition A histone H1.2 that is encoded in the genome of human.
Short Label hHIST1H1C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16403 (HIST1H1C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 21406692, 22223895, ...22814378, 25944712, 20068231
S2 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17081983, ...19007248, 19691289, 19651622, 17043054, 20068231
T4 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17081983, 20058876, ...19691289, 18669648
K17 Acetylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K26 Methylation PhosphoSitePlus
T31 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus 20439994, 17287340, 17081983, ...20068231
K34 Acetylation PhosphoSitePlus
K34 Methylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
S36 Phosphorylation O96017 (CHEK2) HPRD   phospho.ELM   PhosphoSitePlus 17287340, 18212344, 20058876, ...19691289, 19007248, 19651622, 17877366, 18669648, 17043054, 20068231, 17924679
S41 Phosphorylation HPRD   PhosphoSitePlus 19691289, 20068231, 17043054
T45 Phosphorylation PhosphoSitePlus
K46 Acetylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
K52 Methylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
R54 Methylation PhosphoSitePlus
S55 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 17877366
S58 Phosphorylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K64 Sumoylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K75 Methylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
S89 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 17877366
K90 Acetylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
T92 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 17877366
K97 Ubiquitination PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S104 Phosphorylation HPRD   PhosphoSitePlus 17287340
K106 Acetylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K119 Methylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
T146 Phosphorylation P78527 (PRKDC) HPRD   PRO   PhosphoSitePlus   RLIMS-P   UniProt 28392790, 15595731, 20439994, ...24601643, 22249259, 19007248, 20068231
K148 Ubiquitination PhosphoSitePlus
S150 Phosphorylation RLIMS-P 22249259
T154 Phosphorylation PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K160 Acetylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
T165 Phosphorylation HPRD   PhosphoSitePlus 17043054
T167 Phosphorylation O96017 (CHEK2) PhosphoSitePlus 17877366
K168 Acetylation PhosphoSitePlus
K168 Methylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K169 Acetylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S173 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 15595731, 20439994, 22249259, ...16377619, 20068231
K178 Ubiquitination PhosphoSitePlus
K187 Acetylation PhosphoSitePlus
K187 Methylation PhosphoSitePlus   UniProt 20334638
S188 Phosphorylation RLIMS-P 22249259
K191 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044869 (hHIST1H1C/InitMet-/Phos:1) pT31 PRO 20439994
PR:000044870 (hHIST1H1C/InitMet-/Phos:2) pS173 PRO 16377619, 20439994
PR:000044871 (hHIST1H1C/InitMet-/Phos:3) pT146 PRO 20439994


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P16403 (HIST1H1C) T146 P04637 (TP53) unknown eFIP 22249259


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T4 S4 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
T4 N4 Biomuta DOID:3571 / liver cancer [ icgc ]
K21 N21 Biomuta DOID:5041 / esophageal cancer [ tcga ]
K26 E26 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:2531 / hematologic cancer [ icgc ]
T31 K31 Biomuta DOID:3571 / liver cancer [ icgc ]
K52 E52 Biomuta DOID:11934 / head and neck cancer [ tcga ]
R54 S54 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S58 Y58 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
Y71 C71 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K85 N85 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:1324 / lung cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
S89 N89 Biomuta DOID:1909 / melanoma [ tcga ] DOID:2531 / hematologic cancer [ icgc, tcga ]
S104 F104 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K109 N109 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ] DOID:2531 / hematologic cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
K110 N110 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K117 R117 Biomuta DOID:5041 / esophageal cancer [ tcga ]
K119 N119 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K119 R119 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T126 I126 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K129 N129 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:1612 / breast cancer [ cosmic, icgc ]
K136 M136 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K136 N136 Biomuta DOID:1324 / lung cancer [ tcga ]
T154 A154 Biomuta DOID:3571 / liver cancer [ tcga ]
K159 N159 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:11054 / urinary bladder cancer [ tcga ]
K160 E160 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K168 N168 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]
S173 T173 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K178 M178 Biomuta DOID:1324 / lung cancer [ tcga ]
K178 N178 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K196 M196 Biomuta DOID:363 / uterine cancer [ tcga ]
K199 E199 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K206 N206 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]