iPTMnet Report for P16402 (H1-3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16402 / H13_HUMAN
Protein Name Histone H1.3
Gene Name Name: H1-3
Synonyms:H1F3;
Organism Homo sapiens (Human)

PRO ID PR:P16402
DAG View
PRO Name histone H1.3 (human)
Definition A histone H1.3 that is encoded in the genome of human.
Short Label hH1-3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16402 (H1-3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 21406692, 22223895, ...25944712
S2 Phosphorylation PhosphoSitePlus   UniProt 21406692
T4 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20058876, 17081983
T10 Phosphorylation PhosphoSitePlus
K17 Acetylation PhosphoSitePlus
K17 Ubiquitination PhosphoSitePlus
T18 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17287340, ...17081983, 17043054, 23186163
K26 Methylation PhosphoSitePlus
K33 Acetylation PhosphoSitePlus
K35 Acetylation PhosphoSitePlus
K35 Methylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S37 Phosphorylation HPRD   PhosphoSitePlus 17287340, 17081983, 18452278, ...18669648, 20166139, 19415658
S42 Phosphorylation PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
K47 Acetylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
R55 Methylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K65 Methylation PhosphoSitePlus
K65 Sumoylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
Y72 Phosphorylation PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
K98 Methylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
K107 Acetylation PhosphoSitePlus
K107 Methylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T147 Phosphorylation HPRD   PhosphoSitePlus 15595731, 17043054
K149 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
T155 Phosphorylation HPRD 15595731
K160 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
K169 Acetylation PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
T180 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15595731, 17287340
K188 Acetylation PhosphoSitePlus
S189 Phosphorylation HPRD   PhosphoSitePlus 15595731
K207 Acetylation PhosphoSitePlus
K209 Acetylation PhosphoSitePlus
K212 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T4 S4 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
T10 I10 Biomuta DOID:2021 / placenta cancer [ cosmic ]
K17 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K17 I17 Biomuta DOID:4159 / skin cancer [ cosmic ]
T18 A18 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K26 N26 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T46 N46 Biomuta DOID:3571 / liver cancer [ cosmic ]
R55 P55 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S56 T56 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S59 C59 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K64 N64 Biomuta DOID:1612 / breast cancer [ cosmic ]
K64 R64 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y72 D72 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y72 C72 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K76 R76 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K86 Q86 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
K86 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S87 R87 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S87 T87 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S87 N87 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S90 N90 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S90 T90 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T93 I93 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T100 I100 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S105 F105 Biomuta DOID:4159 / skin cancer [ cosmic ]
K107 T107 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K107 N107 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K110 R110 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K118 N118 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K118 E118 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T147 I147 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T147 S147 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S151 N151 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S151 T151 Biomuta DOID:1324 / lung cancer [ cosmic ]
K160 R160 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K161 R161 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T164 S164 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K169 E169 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K169 N169 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K176 N176 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T180 I180 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K188 N188 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K188 R188 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S189 R189 Biomuta DOID:1324 / lung cancer [ cosmic ]
K207 R207 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K209 * Biomuta DOID:1319 / brain cancer [ cosmic ]