iPTMnet Report for P16401 (H1-5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16401 / H15_HUMAN
Protein Name Histone H1.5
Gene Name Name: H1-5
Synonyms:H1F5,HIST1H1B;
Organism Homo sapiens (Human)

PRO ID PR:P16401
DAG View
PRO Name histone H1.5 (human)
Definition A histone H1.5 that is encoded in the genome of human.
Short Label hH1-5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16401 (H1-5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO 19136008
S2 Acetylation UniProt 19413330, 21406692, 22223895, ...22814378, 25944712, 20068231
S2 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 19691289, ...19007248, 19651622, 17043054, 20068231
T4 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16083285, 17043054, 20068231
T9 Phosphorylation HPRD   PhosphoSitePlus 17081983
T11 Phosphorylation HPRD   PRO   PhosphoSitePlus   Signor   UniProt 23186163, 17081983, 19691289, ...16377619, 19007248, 18669648, 19136008, 20068231
T11 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 19136008
T11 Phosphorylation PR:P49841 (hGSK3B) PRO 19136008
K17 Ubiquitination PhosphoSitePlus
S18 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 21406692, 19691289, ...23186163, 18212344, 28539972, 18578522, 16377619, 19007248, 19664995, 17081983, 18669648, 16083285, 24275569, 18452278, 19690332, 20068231, 17043054
K23 Acetylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
K26 Acetylation PhosphoSitePlus
K27 Methylation PhosphoSitePlus   UniProt 19552482
K35 Acetylation PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K37 Methylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
T39 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 19007248
S44 Phosphorylation HPRD   PhosphoSitePlus 19007248, 19691289
T48 Phosphorylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
K55 Acetylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S61 Phosphorylation HPRD   PhosphoSitePlus 19691289
K66 Acetylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
Y74 Phosphorylation PhosphoSitePlus
K78 Acetylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S107 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K109 Acetylation PhosphoSitePlus
K109 Methylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K132 Acetylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K133 Acetylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
T138 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   UniProt 21406692, 15595731, 17081983, ...19007248, 16377619, 20068231
K140 Acetylation PhosphoSitePlus
K143 Acetylation PhosphoSitePlus
K144 Acetylation PhosphoSitePlus
K149 Acetylation PhosphoSitePlus
T155 Phosphorylation HPRD   PRO   PhosphoSitePlus   UniProt 15595731, 16377619
K160 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K168 Acetylation PhosphoSitePlus   UniProt 19608861
K168 Ubiquitination PhosphoSitePlus
S173 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   UniProt 20439994, 17081983, 16377619
T187 Phosphorylation HPRD   PhosphoSitePlus 19007248
S189 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   UniProt 20068231, 19007248, 16377619, ...17081983
K194 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K199 Acetylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K209 Acetylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000029022 (hHIST1H1B/InitMet-/Phos:1) p PRO 19136008
PR:000029022 (hHIST1H1B/InitMet-/Phos:1) pT11 PR:P49841 (hGSK3B) PRO 19136008
PR:000044880 (hHIST1H1B/InitMet-/Phos:2) pT138 PRO 16377619, 19007248
PR:000044881 (hHIST1H1B/InitMet-/Phos:3) pS189 PRO 16377619
PR:000044882 (hHIST1H1B/InitMet-/Phos:4) pS18 PRO 16083285, 16377619
PR:000044883 (hHIST1H1B/InitMet-/Phos:5) pS173 PRO 16377619, 20439994
PR:000044884 (hHIST1H1B/InitMet-/Phos:6) pT11 PRO 16377619, 19136008
PR:000044885 (hHIST1H1B/InitMet-/Phos:7) pT155 PRO 16377619


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T9 I9 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T9 A9 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T11 S11 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S18 T18 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K27 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K27 E27 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K37 Q37 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S44 L44 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S44 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K49 N49 Biomuta DOID:1324 / lung cancer [ cosmic ]
S61 Y61 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S61 C61 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S61 F61 Biomuta DOID:1612 / breast cancer [ cosmic ]
K66 R66 Biomuta DOID:1319 / brain cancer [ icgc ]
K66 E66 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K67 N67 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K78 N78 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K88 N88 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S89 R89 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S89 T89 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S89 I89 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S89 N89 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S92 T92 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S92 R92 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S92 N92 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T95 A95 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T95 P95 Biomuta DOID:3571 / liver cancer [ cosmic ]
T95 I95 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T102 S102 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S105 F105 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K109 R109 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K112 R112 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K113 E113 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K132 E132 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K143 N143 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K144 E144 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K160 N160 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S173 I173 Biomuta DOID:1324 / lung cancer [ cosmic ]
S173 G173 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T187 A187 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T187 I187 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S189 N189 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K197 N197 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K209 E209 Biomuta DOID:2531 / hematologic cancer [ cosmic ]