Protein Information

Cytoscape View


UniProt AC / UniProt ID P16333 / NCK1_HUMAN
Protein Name Cytoplasmic protein NCK1
Gene Name Name: NCK1
Synonyms:NCK;
Organism Homo sapiens (Human)

PRO ID PR:P16333
DAG View
PRO Name cytoplasmic protein NCK1 (human)
Definition A cytoplasmic protein NCK1 that is encoded in the genome of human.
Short Label hNCK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16333 (NCK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
Y13 Phosphorylation PhosphoSitePlus
S61 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
S85 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 17081983, 18669648, ...24275569, 23186163, 19690332
S89 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S91 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S96 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 17287340
Y105 Phosphorylation P00519 (ABL1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17287340, 18088087, 22327338, ...19690332, 20068231
Y112 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
T161 Phosphorylation phospho.ELM 18669648
S166 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
K178 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
Y268 Phosphorylation phospho.ELM   PhosphoSitePlus 16497976
K286 Ubiquitination PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
Y339 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T74 Phosphorylation HPRD 18212344
S85 Phosphorylation HPRD 17287340, 15144186, 19651622, ...18669648, 20166139, 20068231
S89 Phosphorylation HPRD 19651622, 20166139, 18669648
S91 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
S96 Phosphorylation HPRD 18669648, 17287340, 20068231
Y105 Phosphorylation HPRD 17016520, 17389395, 17287340, ...15951569, 18707149, 18088087, 20068231
T161 Phosphorylation HPRD 18669648
S166 Phosphorylation HPRD 18669648, 20068231
Y246 Phosphorylation HPRD 16497976
S262 Phosphorylation HPRD 20068231
Y268 Phosphorylation HPRD 16497976
S312 Phosphorylation HPRD 20068231
S313 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S66 C66 Biomuta DOID:2394 / ovarian cancer [ tcga ]
T74 A74 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T74 I74 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ]
S89 F89 Biomuta DOID:1909 / melanoma [ tcga ]
Y105 C105 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ] DOID:3571 / liver cancer [ tcga ]
T161 A161 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y268 * Biomuta DOID:5041 / esophageal cancer [ icgc ]
Y268 D268 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S313 L313 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]