iPTMnet Report for P16157 (ANK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16157 / ANK1_HUMAN
Protein Name Ankyrin-1
Gene Name Name: ANK1
Synonyms:ANK;
Organism Homo sapiens (Human)

PRO ID PR:P16157
DAG View
PRO Name ankyrin-1 (human)
Definition An ankyrin-1 that is encoded in the genome of human.
Short Label hANK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16157 (ANK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y3 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
T14 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
Y216 Phosphorylation phospho.ELM   PhosphoSitePlus 16497976
S231 Phosphorylation phospho.ELM 18669648
T235 Phosphorylation PhosphoSitePlus
S288 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 18984734
S366 Phosphorylation PhosphoSitePlus
K380 Acetylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus   UniProt 23186163
K436 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
T472 Phosphorylation PhosphoSitePlus
T500 Phosphorylation PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
Y546 Phosphorylation PhosphoSitePlus
S594 Phosphorylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
Y603 Phosphorylation PhosphoSitePlus
T604 Phosphorylation PhosphoSitePlus
Y624 Phosphorylation PhosphoSitePlus
Y702 Phosphorylation PhosphoSitePlus
T703 Phosphorylation PhosphoSitePlus
Y711 Phosphorylation PhosphoSitePlus
Y735 Phosphorylation PhosphoSitePlus
S736 Phosphorylation PhosphoSitePlus
S759 Phosphorylation PhosphoSitePlus   UniProt 23186163
S781 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S794 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 18984734
S817 Phosphorylation PhosphoSitePlus   UniProt 24275569
S826 Phosphorylation PhosphoSitePlus
S834 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S856 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y884 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
S960 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 18984734
T961 Phosphorylation PhosphoSitePlus
Y1073 Phosphorylation PhosphoSitePlus
K1102 Acetylation PhosphoSitePlus
S1162 O-Glycosylation GlyGen   PhosphoSitePlus 30379171, 18984734
T1227 Phosphorylation PhosphoSitePlus
Y1230 Phosphorylation PhosphoSitePlus
Y1259 Phosphorylation PhosphoSitePlus
S1312 Phosphorylation PhosphoSitePlus
T1378 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1380 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1396 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1398 Phosphorylation PhosphoSitePlus
S1428 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y1468 Phosphorylation PhosphoSitePlus
S1486 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1523 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1533 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1593 Phosphorylation PhosphoSitePlus
S1607 Phosphorylation PhosphoSitePlus
S1666 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1671 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1684 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
S1686 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 23186163
T1688 Phosphorylation PhosphoSitePlus
S1690 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1696 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1750 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y216 Phosphorylation HPRD 16497976
S231 Phosphorylation HPRD 18669648
S781 Phosphorylation HPRD 20058876
S817 Phosphorylation HPRD 20166139
S834 Phosphorylation HPRD 19651622, 18669648
S856 Phosphorylation HPRD 19651622, 19664994
T1378 Phosphorylation HPRD 19651622
T1380 Phosphorylation HPRD 19651622
S1666 Phosphorylation HPRD 19651622
T1684 Phosphorylation HPRD 18088087
S1686 Phosphorylation HPRD 19562805, 19651622, 18088087, ...20166139
Site PTM Type PTM Enzyme Score Source PMID
Y216 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
T1378 Phosphorylation PhosphoSitePlus
T1380 Phosphorylation PhosphoSitePlus
T1500 Phosphorylation PhosphoSitePlus
Y1504 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S55 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K41 Acetylation PhosphoSitePlus
K42 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y216 Phosphorylation HPRD 16497976
S231 Phosphorylation HPRD 18669648
S781 Phosphorylation HPRD 20058876
S817 Phosphorylation HPRD 20166139
S834 Phosphorylation HPRD 19651622, 18669648
S856 Phosphorylation HPRD 19651622, 19664994
T1378 Phosphorylation HPRD 19651622
T1380 Phosphorylation HPRD 19651622
S1666 Phosphorylation HPRD 19651622
T1684 Phosphorylation HPRD 18088087
S1686 Phosphorylation HPRD 19562805, 19651622, 18088087, ...20166139
Site PTM Type PTM Enzyme Score Source PMID
Y216 Phosphorylation HPRD 16497976
S231 Phosphorylation HPRD 18669648
S781 Phosphorylation HPRD 20058876
S817 Phosphorylation HPRD 20166139
S834 Phosphorylation HPRD 19651622, 18669648
S856 Phosphorylation HPRD 19651622, 19664994
T1378 Phosphorylation HPRD 19651622
T1380 Phosphorylation HPRD 19651622
T1522 Phosphorylation HPRD 18088087
S1524 Phosphorylation HPRD 19562805, 19651622, 18088087, ...20166139
Site PTM Type PTM Enzyme Score Source PMID
Y216 Phosphorylation HPRD 16497976
S231 Phosphorylation HPRD 18669648
S781 Phosphorylation HPRD 20058876
S817 Phosphorylation HPRD 20166139
S834 Phosphorylation HPRD 19651622, 18669648
S856 Phosphorylation HPRD 19651622, 19664994
T1378 Phosphorylation HPRD 19651622
T1380 Phosphorylation HPRD 19651622
S1666 Phosphorylation HPRD 19651622
T1684 Phosphorylation HPRD 18088087
S1686 Phosphorylation HPRD 19562805, 19651622, 18088087, ...20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K42 N42 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
T208 M208 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T208 K208 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S429 L429 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T500 I500 Biomuta DOID:4159 / skin cancer [ cosmic ]
K534 T534 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S594 F594 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y603 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S736 N736 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S781 Y781 Biomuta DOID:363 / uterine cancer [ icgc ]
S826 N826 Biomuta DOID:1319 / brain cancer [ cosmic ]
S834 F834 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S960 N960 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1102 T1102 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1227 I1227 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y1230 H1230 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y1259 C1259 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1380 M1380 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1380 K1380 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1396 Y1396 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S1396 F1396 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1468 C1468 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y1468 H1468 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1523 P1523 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T1688 I1688 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]