Protein Information

Cytoscape View


UniProt AC / UniProt ID P16150 / LEUK_HUMAN
Protein Name Leukosialin precursor
Gene Name Name: SPN
Synonyms:CD43;
Organism Homo sapiens (Human)

PRO ID PR:P16150
DAG View
PRO Name leukosialin (human)
Definition A leukosialin that is encoded in the genome of human.
Short Label hSPN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16150 (SPN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T21 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T22 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T26 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T28 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
S29 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
S35 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T36 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
S37 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
S41 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
S42 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T46 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T47 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
S48 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T50 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T58 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T69 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T93 O-Glycosylation GlyGen 30459171
T94 O-Glycosylation GlyGen 30459171
S99 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
S103 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T109 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T113 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
S114 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T136 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T137 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T153 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
T173 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
T178 O-Glycosylation GlyGen   UniProt 2971663, 2943741, 2033371, ...1731338, 6725284
S211 Phosphorylation PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
N239 N-Glycosylation GlyGen   UniProt 1731338
S291 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 2530225, 23186163
S328 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus   UniProt 23186163
S337 O-Glycosylation GlyGen 29351928
S337 Phosphorylation PhosphoSitePlus
T341 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20166139, 23186163
T343 Phosphorylation PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
S351 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   UniProt 19651622, 20058876, 2530225, ...23186163
S355 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18088087, 23186163, 19651622, ...20058876
K362 Ubiquitination PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus   UniProt 19690332


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036621 (hMSN/iso:1/Phos:1) Interaction PR:P16150 (hSPN) PRO 18025306


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 C37 Biomuta DOID:1324 / lung cancer [ cosmic ]
S41 G41 Biomuta DOID:363 / uterine cancer [ tcga ]
T50 A50 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T93 A93 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S99 F99 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T153 M153 Biomuta DOID:1324 / lung cancer [ tcga ] DOID:263 / kidney cancer [ cosmic, icgc ]
N239 S239 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]