iPTMnet Report P16150 SPN

Protein Information

UniProt AC / UniProt ID	P16150 / LEUK_HUMAN
Protein Name	Leukosialin precursor
Gene Name	Name: SPN Synonyms:CD43;
Organism	Homo sapiens (Human)

PRO ID	PR:P16150 DAG View
PRO Name	leukosialin (human)
Definition	A leukosialin that is encoded in the genome of human.
Short Label	hSPN
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P16150 (SPN) as Substrate

P16150

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine By position T21 T22 T26 T28 S29 S35 T36 S37 S41 S42 T46 T47 S48 T50 T58 T69 T93 T94 S99 S103 T109 T113 S114 T136 T137 T153 S156 T173 T178 S211 T236 N239 S291 S328 S336 S337 T341 T343 T344 S351 S355 K362 S363 S365 S368	PTM Type Select all N-Glycosylation O-Glycosylation Phosphorylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all GlyGen HPRD IEDB PhosphoSitePlus RLIMS-P+ UniProt phospho.ELM	PMID
T21	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T22	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T26	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T28	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
S29	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
S35	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T36	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
S37	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
S41	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
S42	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T46	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T47	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
S48	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T50	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T58	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T69	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T93	O-Glycosylation		score1	GlyGen	30459171
T94	O-Glycosylation		score1	GlyGen	30459171
S99	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
S103	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T109	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T113	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
S114	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T136	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T137	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T153	Phosphorylation		score1	PhosphoSitePlus
S156	Phosphorylation		score1	PhosphoSitePlus
T173	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
T178	O-Glycosylation		score4	GlyGen UniProt	2971663, 2943741, 2033371, ...1731338, 6725284
S211	Phosphorylation		score1	PhosphoSitePlus
T236	Phosphorylation		score1	PhosphoSitePlus
N239	N-Glycosylation		score3	GlyGen UniProt	1731338
S291	Phosphorylation		score4	HPRD PhosphoSitePlus UniProt	19651622, 2530225, 23186163
S328	Phosphorylation		score1	PhosphoSitePlus
S336	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S337	O-Glycosylation		score1	GlyGen	29351928
S337	Phosphorylation		score1	PhosphoSitePlus
T341	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	20166139, 23186163
T343	Phosphorylation		score1	PhosphoSitePlus
T344	Phosphorylation		score1	PhosphoSitePlus
S351	Phosphorylation	P17252 (PRKCA)	score4	HPRD IEDB phospho.ELM PhosphoSitePlus RLIMS-P+ UniProt	35494241, 23186163, 20058876, ...2530225, 19651622
S355	Phosphorylation		score2	HPRD IEDB phospho.ELM PhosphoSitePlus UniProt	35494241, 23186163, 20058876, ...19651622, 18088087
K362	Ubiquitination		score1	PhosphoSitePlus
S363	Phosphorylation		score1	PhosphoSitePlus
S365	Phosphorylation		score1	PhosphoSitePlus
S368	Phosphorylation		score2	PhosphoSitePlus UniProt	19690332

Proteoform PPIs

Search:

	Protein 1 Select all PR:000036621 (hMSN/iso:1/Phos:1)	Relation Select all Interaction	Protein 2 Select all PR:P16150 (hSPN)	Source Select all PRO	PMID
	PR:000036621 (hMSN/iso:1/Phos:1)	Interaction	PR:P16150 (hSPN)	PRO	18025306

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position S37 S99 T153 N239	Variant Select all C37 F99 M153 S239	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
S37	C37	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S99	F99	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
T153	M153	Biomuta	DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
N239	S239	Biomuta	DOID:3571 / liver cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P16150 (SPN)

Protein Information

Interactive Sequence View

P16150 (SPN) as Substrate

Proteoform PPIs

PTM sites affected in variants