iPTMnet Report for P16144 (ITGB4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16144 / ITB4_HUMAN
Protein Name Integrin beta-4 precursor
Gene Name Name: ITGB4
Organism Homo sapiens (Human)

PRO ID PR:P16144
DAG View
PRO Name integrin beta-4 (human)
Definition An integrin beta-4 that is encoded in the genome of human.
Short Label hITGB4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16144 (ITGB4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T210 Phosphorylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
T383 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
Y408 Phosphorylation PhosphoSitePlus
K437 Sumoylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
K662 Ubiquitination PhosphoSitePlus
T681 Phosphorylation PhosphoSitePlus
N695 N-Glycosylation GlyGen   UniProt 16335952
K758 Ubiquitination PhosphoSitePlus
Y762 Phosphorylation PhosphoSitePlus
S771 Phosphorylation PhosphoSitePlus
T776 Phosphorylation PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus
S821 Phosphorylation PhosphoSitePlus
T829 Phosphorylation PhosphoSitePlus
K834 Ubiquitination PhosphoSitePlus
T837 Phosphorylation PhosphoSitePlus
Y855 Phosphorylation PhosphoSitePlus
K863 Ubiquitination PhosphoSitePlus
K868 Ubiquitination PhosphoSitePlus
T886 Phosphorylation PhosphoSitePlus
S893 Phosphorylation PhosphoSitePlus
K895 Ubiquitination PhosphoSitePlus
K904 Ubiquitination PhosphoSitePlus
K915 Ubiquitination PhosphoSitePlus
Y920 Phosphorylation PhosphoSitePlus
Y921 Phosphorylation PhosphoSitePlus
T922 Phosphorylation PhosphoSitePlus
K958 Ubiquitination PhosphoSitePlus
T971 Phosphorylation PhosphoSitePlus
T973 Phosphorylation PhosphoSitePlus
T982 Phosphorylation PhosphoSitePlus
S1000 Phosphorylation PhosphoSitePlus
K1021 Ubiquitination PhosphoSitePlus
Y1039 Phosphorylation PhosphoSitePlus
K1055 Ubiquitination PhosphoSitePlus
K1060 Ubiquitination PhosphoSitePlus
S1069 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1084 Phosphorylation PhosphoSitePlus
S1097 Phosphorylation PhosphoSitePlus
T1098 Phosphorylation PhosphoSitePlus
T1099 Phosphorylation PhosphoSitePlus
S1140 Phosphorylation PhosphoSitePlus
S1167 Phosphorylation PhosphoSitePlus
S1180 Phosphorylation PhosphoSitePlus
Y1187 Phosphorylation PhosphoSitePlus
Y1189 Phosphorylation PhosphoSitePlus
Y1199 Phosphorylation PhosphoSitePlus
Y1207 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 15951569
S1208 Phosphorylation PhosphoSitePlus
S1209 Phosphorylation PhosphoSitePlus
T1246 Phosphorylation PhosphoSitePlus
Y1257 Phosphorylation phospho.ELM   PhosphoSitePlus 11438664
T1297 Phosphorylation PhosphoSitePlus
T1318 Phosphorylation PhosphoSitePlus
S1325 Phosphorylation PhosphoSitePlus
Y1343 Phosphorylation PhosphoSitePlus
S1345 Phosphorylation PhosphoSitePlus
Y1349 Phosphorylation PhosphoSitePlus
S1350 Phosphorylation PhosphoSitePlus
S1356 Phosphorylation phospho.ELM   PhosphoSitePlus 20870721, 15121854
S1356 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 15121854
S1356 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 20870721
S1360 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 17615294, 15121854
S1360 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 17615294, 15121854
S1364 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17615294, 15121854, 20870721
S1364 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 15121854
S1364 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 17615294
S1364 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus 20870721
S1403 Phosphorylation PhosphoSitePlus
S1428 Phosphorylation PhosphoSitePlus
T1434 Phosphorylation PhosphoSitePlus
S1454 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1455 Phosphorylation PhosphoSitePlus
S1457 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 34924769, 23186163
S1465 Phosphorylation PhosphoSitePlus
Y1469 Phosphorylation PhosphoSitePlus
T1471 Phosphorylation PhosphoSitePlus
S1474 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1483 O-Glycosylation GlyGen 31492838, 34019948, 28657654, ...29237092, 35254053
S1483 Phosphorylation PhosphoSitePlus
T1484 O-Glycosylation GlyGen 31492838, 34019948, 28657654, ...29237092, 35254053
T1484 Phosphorylation PhosphoSitePlus
S1485 O-Glycosylation GlyGen 31492838, 34019948, 28657654, ...29237092, 35254053
S1485 Phosphorylation PhosphoSitePlus
S1486 O-Glycosylation GlyGen 31492838, 34019948, 28657654, ...29237092, 35254053
S1486 Phosphorylation PhosphoSitePlus
T1487 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1489 Phosphorylation PhosphoSitePlus
Y1492 Phosphorylation PhosphoSitePlus
S1494 Phosphorylation PhosphoSitePlus   Signor 15121854, 19005215
S1494 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 15121854, 19005215
T1496 Phosphorylation PhosphoSitePlus
S1498 Phosphorylation PhosphoSitePlus
S1501 Phosphorylation PhosphoSitePlus
S1503 Phosphorylation PhosphoSitePlus
T1504 Phosphorylation PhosphoSitePlus
T1505 Phosphorylation PhosphoSitePlus
Y1510 Phosphorylation PhosphoSitePlus
S1511 Phosphorylation PhosphoSitePlus
T1512 Phosphorylation PhosphoSitePlus
T1514 Phosphorylation PhosphoSitePlus
S1515 Phosphorylation PhosphoSitePlus
S1517 Phosphorylation PhosphoSitePlus
S1518 Phosphorylation PhosphoSitePlus
S1521 Phosphorylation PhosphoSitePlus
T1524 Phosphorylation PhosphoSitePlus
T1530 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243
S1537 Phosphorylation PhosphoSitePlus
S1547 Phosphorylation PhosphoSitePlus
Y1564 Phosphorylation phospho.ELM   PhosphoSitePlus 11438664, 23677256
Y1564 Phosphorylation P11362 (FGFR1) PhosphoSitePlus 23677256
S1595 Phosphorylation PhosphoSitePlus
Y1596 Phosphorylation PhosphoSitePlus
S1604 Phosphorylation PhosphoSitePlus
S1653 Phosphorylation PhosphoSitePlus
Y1674 Phosphorylation PhosphoSitePlus
T1688 Phosphorylation PhosphoSitePlus
S1696 Phosphorylation PhosphoSitePlus
S1707 Phosphorylation PhosphoSitePlus
T1720 Phosphorylation PhosphoSitePlus
T1721 Phosphorylation PhosphoSitePlus
S1747 Phosphorylation PhosphoSitePlus
S1758 Phosphorylation PhosphoSitePlus
Y1760 Phosphorylation PhosphoSitePlus
S1761 Phosphorylation PhosphoSitePlus
S1762 Phosphorylation PhosphoSitePlus
T1764 Phosphorylation PhosphoSitePlus
T1765 Phosphorylation PhosphoSitePlus
T1766 Phosphorylation PhosphoSitePlus
T1771 Phosphorylation PhosphoSitePlus
S1791 Phosphorylation PhosphoSitePlus
T1793 Phosphorylation PhosphoSitePlus
T1797 Phosphorylation PhosphoSitePlus
T1804 Phosphorylation PhosphoSitePlus
T1806 Phosphorylation PhosphoSitePlus
T1807 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S179 Phosphorylation HPRD 20068231
S1084 Phosphorylation HPRD 17924679
Y1207 Phosphorylation HPRD 15951569, 17389395
Y1469 Phosphorylation HPRD 17081983
T1471 Phosphorylation HPRD 19651622
S1474 Phosphorylation HPRD 17081983
Y1510 Phosphorylation HPRD 17389395, 18707149
T1530 Phosphorylation HPRD 16964243
Site PTM Type PTM Enzyme Score Source PMID
S179 Phosphorylation HPRD 20068231
Y855 Phosphorylation PhosphoSitePlus
Y920 Phosphorylation PhosphoSitePlus
S1084 Phosphorylation HPRD 17924679
Y1189 Phosphorylation PhosphoSitePlus
Y1207 Phosphorylation HPRD   PhosphoSitePlus 15951569, 17389395
Y1343 Phosphorylation PhosphoSitePlus
Y1349 Phosphorylation PhosphoSitePlus
S1356 Phosphorylation PhosphoSitePlus
S1358 Phosphorylation PhosphoSitePlus
S1360 Phosphorylation PhosphoSitePlus
S1364 Phosphorylation PhosphoSitePlus
S1366 Phosphorylation PhosphoSitePlus
Y1399 Phosphorylation HPRD   PhosphoSitePlus 17081983
T1401 Phosphorylation HPRD 19651622
S1404 Phosphorylation HPRD   PhosphoSitePlus 17081983
S1413 Phosphorylation PhosphoSitePlus
S1415 Phosphorylation PhosphoSitePlus
S1416 Phosphorylation PhosphoSitePlus
T1417 Phosphorylation PhosphoSitePlus
Y1422 Phosphorylation PhosphoSitePlus
S1424 Phosphorylation PhosphoSitePlus
Y1440 Phosphorylation HPRD   PhosphoSitePlus 17389395, 18707149
T1460 Phosphorylation HPRD 16964243
Y1494 Phosphorylation PhosphoSitePlus
Y1526 Phosphorylation PhosphoSitePlus
S1534 Phosphorylation PhosphoSitePlus
Y1642 Phosphorylation PhosphoSitePlus
Y1690 Phosphorylation PhosphoSitePlus
T1727 Phosphorylation PhosphoSitePlus
T1736 Phosphorylation PhosphoSitePlus 22357621, 26580203
T1736 Phosphorylation Q15139 (PRKD1) PhosphoSitePlus 22357621
T1736 Phosphorylation Q9BZL6 (PRKD2) PhosphoSitePlus 26580203
T1737 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S179 Phosphorylation HPRD 20068231
S1084 Phosphorylation HPRD 17924679
Y1207 Phosphorylation HPRD 15951569, 17389395
S1356 Phosphorylation PhosphoSitePlus
S1358 Phosphorylation PhosphoSitePlus
S1360 Phosphorylation PhosphoSitePlus
S1364 Phosphorylation PhosphoSitePlus
S1366 Phosphorylation PhosphoSitePlus
Y1399 Phosphorylation HPRD 17081983
T1401 Phosphorylation HPRD 19651622
S1404 Phosphorylation HPRD 17081983
Y1440 Phosphorylation PhosphoSitePlus
S1441 Phosphorylation PhosphoSitePlus
S1488 Phosphorylation PhosphoSitePlus
T1513 Phosphorylation HPRD 16964243


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 R7 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S102 P102 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T164 N164 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S368 F368 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T383 I383 Biomuta DOID:1612 / breast cancer [ cosmic ]
S387 F387 Biomuta DOID:4159 / skin cancer [ cosmic ]
S397 F397 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K662 T662 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
N695 T695 Biomuta DOID:4159 / skin cancer [ cosmic ]
K758 T758 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K915 M915 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y921 C921 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T973 I973 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S1084 N1084 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1099 I1099 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1167 F1167 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1180 L1180 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1358 L1358 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1399 F1399 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y1399 H1399 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y1440 C1440 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1441 F1441 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1457 Y1457 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1469 H1469 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y1469 F1469 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1488 C1488 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y1494 C1494 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1494 H1494 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc, cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S1498 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1498 L1498 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1510 C1510 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1511 F1511 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1517 Y1517 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1521 C1521 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1564 H1564 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1564 C1564 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1595 Y1595 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S1707 R1707 Biomuta DOID:184 / bone cancer [ cosmic ]
T1793 A1793 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1804 A1804 Biomuta DOID:363 / uterine cancer [ icgc ]