iPTMnet Report for P16118 (PFKFB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16118 / F261_HUMAN
Protein Name 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
Gene Name Name: PFKFB1
Synonyms:F6PK,PFRX;
Organism Homo sapiens (Human)

PRO ID PR:P16118
DAG View
PRO Name 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (human)
Definition A 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 that is encoded in the genome of human.
Short Label hPFKFB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16118 (PFKFB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 O-Glycosylation GlyGen 29485866, 28411811, 35254053
S2 Phosphorylation PhosphoSitePlus
T9 O-Glycosylation GlyGen 29485866, 28411811, 35254053
S24 Phosphorylation PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
Y204 Phosphorylation PhosphoSitePlus
Y227 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
Y438 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20166139
S33 Phosphorylation HPRD   PRO 6330071
Y438 Phosphorylation HPRD 19651622


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000026776 (hPFKFB1/InitMet-/Phos:1) pS33 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y204 C204 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y243 H243 Biomuta DOID:4159 / skin cancer [ cosmic, icgc, tcga ]
K364 N364 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]