iPTMnet Report for P16112 (ACAN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16112 / PGCA_HUMAN
Protein Name Aggrecan core protein precursor
Gene Name Name: ACAN
Synonyms:AGC1,CSPG1,MSK16;
Organism Homo sapiens (Human)

PRO ID PR:P16112
DAG View
PRO Name aggrecan core protein (human)
Definition An aggrecan core protein that is encoded in the genome of human.
Short Label hACAN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16112 (ACAN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T22 O-Glycosylation GlyGen 30459171
S23 O-Glycosylation GlyGen 30459171
S30 O-Glycosylation GlyGen 30459171
T45 Phosphorylation IEDB 35494241
T61 O-Glycosylation GlyGen 30459171
S65 O-Glycosylation GlyGen 30459171
S105 O-Glycosylation GlyGen 29351928
N333 N-Glycosylation GlyGen 23090970, 24190977
T371 O-Glycosylation GlyGen   UniProt 1569188, 30459171
T374 O-Glycosylation GlyGen 30459171
T376 O-Glycosylation GlyGen   UniProt 1569188, 30459171
T400 O-Glycosylation GlyGen 30459171
S408 O-Glycosylation GlyGen 30459171
T436 O-Glycosylation GlyGen 30459171
T440 O-Glycosylation GlyGen 30459171
T447 O-Glycosylation GlyGen 30459171
T466 O-Glycosylation GlyGen 30459171
Y536 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
N658 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 29671580, ...30237853
T703 O-Glycosylation GlyGen 30459171
T905 O-Glycosylation GlyGen 30459171
S906 O-Glycosylation GlyGen 30459171
T907 O-Glycosylation GlyGen 30459171
S910 O-Glycosylation GlyGen 30459171
T1080 O-Glycosylation GlyGen 30459171
T1383 O-Glycosylation GlyGen 30459171
T1461 O-Glycosylation GlyGen 30459171
S1530 O-Glycosylation GlyGen   UniProt 36213313
S1567 O-Glycosylation GlyGen   UniProt 36213313
S1567 Phosphorylation PhosphoSitePlus
S1571 Phosphorylation PhosphoSitePlus
S1591 O-Glycosylation GlyGen 30459171
S1599 O-Glycosylation GlyGen 30459171
S1601 O-Glycosylation GlyGen   UniProt 36213313
T1622 O-Glycosylation GlyGen 30459171
S1623 O-Glycosylation GlyGen 30459171
S1630 O-Glycosylation GlyGen 30459171
T1683 O-Glycosylation GlyGen 30459171
S1693 O-Glycosylation GlyGen 30459171
S1703 O-Glycosylation GlyGen   UniProt 36213313
S1720 O-Glycosylation GlyGen 30459171
T1842 O-Glycosylation GlyGen 30459171
S1856 O-Glycosylation GlyGen 30459171
T1881 O-Glycosylation GlyGen 30459171
T1888 O-Glycosylation GlyGen 30459171
S1889 O-Glycosylation GlyGen 30459171
T1891 O-Glycosylation GlyGen 30459171
S1895 O-Glycosylation GlyGen 30459171
S1899 O-Glycosylation GlyGen 30459171
S1915 O-Glycosylation GlyGen 30459171
T1927 O-Glycosylation GlyGen 30459171
S1929 O-Glycosylation GlyGen 30459171
S1930 O-Glycosylation GlyGen 30459171
T1933 O-Glycosylation GlyGen 30459171
T1946 O-Glycosylation GlyGen 30459171
T1950 O-Glycosylation GlyGen 30459171
S1959 O-Glycosylation GlyGen 30459171
S1969 O-Glycosylation GlyGen 30459171
T2035 O-Glycosylation GlyGen 30459171
T2046 O-Glycosylation GlyGen 30459171
T2049 O-Glycosylation GlyGen 30459171
T2061 O-Glycosylation GlyGen 30459171
T2063 O-Glycosylation GlyGen 30459171
T2083 O-Glycosylation GlyGen 30459171
S2101 O-Glycosylation GlyGen 30459171
T2103 O-Glycosylation GlyGen 30459171
S2124 O-Glycosylation GlyGen 30459171
T2132 O-Glycosylation GlyGen 30459171
T2133 O-Glycosylation GlyGen 30459171
S2134 O-Glycosylation GlyGen 30459171
S2144 O-Glycosylation GlyGen 30459171
T2188 O-Glycosylation GlyGen 30459171
T2190 O-Glycosylation GlyGen 30459171
T2196 O-Glycosylation GlyGen 30459171
S2214 O-Glycosylation GlyGen 30459171
T2215 O-Glycosylation GlyGen 30459171
T2223 O-Glycosylation GlyGen 30459171
T2226 O-Glycosylation GlyGen 30459171
S2238 O-Glycosylation GlyGen 30459171
S2239 O-Glycosylation GlyGen 30459171
S2240 O-Glycosylation GlyGen 30459171
T2255 O-Glycosylation GlyGen 30459171
T2258 O-Glycosylation GlyGen 30459171
S2272 Phosphorylation PhosphoSitePlus
S2274 Phosphorylation PhosphoSitePlus
T2275 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N658 N-Glycosylation PRO 29671580
Site PTM Type PTM Enzyme Score Source PMID
Y2410 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S30 T30 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S65 Y65 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S105 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T374 A374 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T376 S376 Biomuta DOID:1324 / lung cancer [ cosmic ]
T376 N376 Biomuta DOID:4159 / skin cancer [ cosmic ]
S408 F408 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T440 A440 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S906 F906 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S910 L910 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1622 K1622 Biomuta DOID:1319 / brain cancer [ cosmic ]
T1622 A1622 Biomuta DOID:3565 / meningioma [ cosmic ]
S1703 R1703 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1703 T1703 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1720 Y1720 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1889 F1889 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S1915 N1915 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T1927 A1927 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1930 I1930 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T1933 I1933 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1950 K1950 Biomuta DOID:3571 / liver cancer [ cosmic ]
T2046 A2046 Biomuta DOID:4159 / skin cancer [ cosmic ]
T2103 K2103 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T2103 M2103 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T2103 A2103 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S2124 F2124 Biomuta DOID:363 / uterine cancer [ icgc ]
S2124 Y2124 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T2132 P2132 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S2144 F2144 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T2226 A2226 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]