Protein Information

Cytoscape View


UniProt AC / UniProt ID P16104 / H2AX_HUMAN
Protein Name Histone H2AX
Gene Name Name: H2AX
Synonyms:H2AFX;
Organism Homo sapiens (Human)

PRO ID PR:P16104
DAG View
PRO Name histone H2AX (human)
Definition A histone H2AX that is encoded in the genome of human.
Short Label hH2AFX
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16104 (H2AX) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 9488723
K6 Acetylation PRO 17709392
K10 Acetylation PRO 18552846, 12937907
K14 Ubiquitination UniProt 22980979
K16 Ubiquitination UniProt 22980979
S19 Phosphorylation PhosphoSitePlus   RLIMS-P 33574926
T102 O-Glycosylation GlyGen 21896475, 27458206
K119 Acetylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PRO 18400894, 15386022
T121 Phosphorylation HPRD   phospho.ELM 16083285, 20068231
S122 Phosphorylation HPRD 19007248, 20068231
T124 Phosphorylation phospho.ELM 16083285
K134 Methylation PhosphoSitePlus
K134 Sumoylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
T137 Phosphorylation HPRD   neXtProt 9488723, 20356835
S140 O-Glycosylation GlyGen 21896475, 27458206
S140 Phosphorylation Q13315 (ATM) , P45984 (MAPK9) , P45983 (MAPK8) HPRD   IntAct   neXtProt   phospho.ELM   PRO   RLIMS-P   Signor   UniProt 10959836, 9488723, 25923214, ...17525332, 12607005, 11571274, 26124332, 15059890, 20118229, 22154951, 18158901, 10734083, 15489221, 19234442, 20356835, 11673449, 16818236, 12697768, 21406692, 14627815, 22064073, 10477747, 12419185, 21690091, 18370922, 15613478, 11893489, 12660252, 20068231
Q141 Phosphorylation IntAct 12607005
Y143 Phosphorylation Q9UIG0 (BAZ1B) PRO   Signor   UniProt 19234442, 19092802


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045018 (hH2AFX/InitMet-/Ac:1) acK6 PRO 17709392
PR:000045019 (hH2AFX/InitMet-/Ubiq:1) ubK120 PRO 15386022, 18400894
PR:000045020 (hH2AFX/InitMet-/Phos:1) pY143 PRO 19092802
PR:000045021 (hH2AFX/InitMet-/Ac:2) acK10 PRO 12937907, 18552846
PR:000045022 (hH2AFX/InitMet-/Phos:2) pS140 PRO 10734083, 10959836, 10959836, ...12660252, 18370922


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P16104 (H2AX) S140 Q6ZW49 (PAXIP1) unknown eFIP 22064073
Phosphorylation P16104 (H2AX) S140 O15297 (PPM1D) unknown eFIP 20118229
Phosphorylation P16104 (H2AX) S140 Q99986 (VRK1) unknown eFIP 25923214
Phosphorylation Q13315 (ATM) S1981 P16104 (H2AX) unknown eFIP 16858402
Phosphorylation Q9NUW8 (TDP1) S81 P16104 (H2AX) unknown eFIP 19851285


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K134 N134 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]