iPTMnet Report for P16066 (NPR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P16066 / ANPRA_HUMAN
Protein Name Atrial natriuretic peptide receptor 1 precursor
Gene Name Name: NPR1
Synonyms:ANPRA;
Organism Homo sapiens (Human)

PRO ID PR:P16066
DAG View
PRO Name atrial natriuretic peptide receptor 1 (human)
Definition An atrial natriuretic peptide receptor 1 that is encoded in the genome of human.
Short Label hNPR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P16066 (NPR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K315 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus   UniProt 20977274
S529 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 9528788, 20977274
S529 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 9528788
T532 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 9528788, 20977274
S534 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 9528788, 20977274
S538 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 9528788, 20977274
S542 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 9528788
T545 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 9528788
K567 Ubiquitination PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
T702 Phosphorylation PhosphoSitePlus
S711 Phosphorylation PhosphoSitePlus
S747 Phosphorylation IEDB 32387766
S809 Phosphorylation PhosphoSitePlus
T835 Phosphorylation PhosphoSitePlus
Y927 Phosphorylation PhosphoSitePlus
K1041 Acetylation PhosphoSitePlus
K1045 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S505 L505 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S519 N519 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S529 R529 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S538 F538 Biomuta DOID:4159 / skin cancer [ cosmic ]
S542 F542 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T702 K702 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T702 M702 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S747 N747 Biomuta DOID:363 / uterine cancer [ icgc ]