iPTMnet Report for P15976 (GATA1)
Protein Information
| UniProt AC / UniProt ID | P15976 / GATA1_HUMAN |
| Protein Name | Erythroid transcription factor |
| Gene Name | Name: GATA1 Synonyms:ERYF1,GF1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P15976 |
| PRO Name | erythroid transcription factor (human) |
| Definition | An erythroid transcription factor that is encoded in the genome of human. |
| Short Label | hGATA1 |
| Category | organism-gene |
P15976 (GATA1) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S26 | Phosphorylation | P27361 (MAPK3) | score4 | neXtProt PhosphoSitePlus RLIMS-P | 15967790, 20101202 | |
| S72 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y78 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S91 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S116 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S131 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K137 | Sumoylation | score1 | PhosphoSitePlus | |||
| S142 | Phosphorylation | score2 | UniProt | 16371476 | ||
| S161 | Phosphorylation | Q9P286 (PAK5) | score3 | PhosphoSitePlus RLIMS-P | 25726523 | |
| S178 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S187 | Phosphorylation | Q9P286 (PAK5) | score3 | PhosphoSitePlus RLIMS-P | 25726523 | |
| Y223 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C228 | Methylation | score1 | IEDB | 31844290 | ||
| Y231 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K233 | Acetylation | score2 | UniProt | 9859997 | ||
| K245 | Acetylation | score3 | PhosphoSitePlus UniProt | 9859997 | ||
| K246 | Acetylation | score3 | PhosphoSitePlus UniProt | 9859997 | ||
| C282 | Methylation | score1 | IEDB | 31844290 | ||
| Y285 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y286 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T304 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S310 | Phosphorylation | P31749 (AKT1) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 16107690, 26680303 | |
| K312 | Acetylation | score1 | PhosphoSitePlus | |||
| K314 | Acetylation | score1 | PhosphoSitePlus | |||
| K315 | Acetylation | score1 | PhosphoSitePlus | |||
| K316 | Acetylation | score1 | PhosphoSitePlus | |||
| S319 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S320 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T324 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S26 | Phosphorylation | score1 | HPRD | 8206977 | ||
| S72 | Phosphorylation | score1 | HPRD | 8206977 | ||
| S116 | Phosphorylation | score0 | HPRD | 19651622 | ||
| K137 | Sumoylation | score2 | PRO | 16371476 | ||
| S142 | Phosphorylation | score4 | HPRD PRO | 8206977, 16371476 | ||
| S187 | Phosphorylation | score1 | HPRD | 8206977 | ||
| S310 | Phosphorylation | P31749 (AKT1) | score2 | HPRD | 8206977, 16107690 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000027073 (hGATA1/iso:1/PhosSumo:1) | pS142 | PRO | 16371476 | ||
| PR:000027073 (hGATA1/iso:1/PhosSumo:1) | suK137 | PRO | 16371476 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S26 | F26 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S72 | P72 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| Y78 | C78 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
| S116 | C116 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S131 | N131 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S161 | T161 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| S178 | C178 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| S178 | R178 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S187 | F187 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| Y231 | H231 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K245 | E245 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| C282 | S282 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| Y286 | C286 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K314 | E314 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
| S319 | C319 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
DAG View