iPTMnet Report for P15941 (MUC1)
Protein Information
| UniProt AC / UniProt ID | P15941 / MUC1_HUMAN |
| Protein Name | Mucin-1 precursor |
| Gene Name | Name: MUC1 Synonyms:PUM; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P15941 |
| PRO Name | mucin-1 (human) |
| Definition | A mucin-1 that is encoded in the genome of human. |
| Short Label | hMUC1 |
| Category | organism-gene |
DAG ViewP15941 (MUC1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S29 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| T30 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| S130 | O-Glycosylation | score1 | GlyGen | 33214551, 35132862, 30059200 | ||
| T131 | O-Glycosylation | score4 | GlyGen IEDB UniProt | 33214551, 33211039, 35132862, ... | ||
| T139 | O-Glycosylation | score4 | GlyGen UniProt | 33214551, 7744025, 35132862, ... | ||
| T144 | O-Glycosylation | score2 | IEDB | 28025250 | ||
| T239 | O-Glycosylation | score1 | GlyGen | 33214551, 35132862, 30059200 | ||
| T279 | O-Glycosylation | score1 | GlyGen | 33214551, 35132862, 30059200 | ||
| T911 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| T919 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| T924 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| S930 | O-Glycosylation | score1 | GlyGen | 30459171 | ||
| S989 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| T990 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| S993 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| S999 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| T1001 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| T1003 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| T1004 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| S1009 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| T1010 | O-Glycosylation | score2 | GlyGen PhosphoSitePlus | 23584533 | ||
| N1055 | N-Glycosylation | score1 | GlyGen | 29741879 | ||
| S1090 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1125 | Acetylation | score1 | PhosphoSitePlus | |||
| Y1191 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
| T1202 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1203 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 14521915, 14766232, 15471854, ... | ||
| Y1203 | Phosphorylation | P09619 (PDGFRB) | score3 | neXtProt PhosphoSitePlus | 17545600 | |
| Y1203 | Phosphorylation | P43403 (ZAP70) | score1 | Signor | 14766232 | |
| S1207 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1209 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18083107 | ||
| T1211 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1212 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus UniProt | 18083107, 14521915 | ||
| T1214 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1218 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus UniProt | 18083107, 17545600 | ||
| Y1218 | Phosphorylation | P09619 (PDGFRB) | score3 | neXtProt PhosphoSitePlus | 17545600 | |
| S1222 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1223 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1224 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus Signor UniProt | 11877440 | ||
| T1224 | Phosphorylation | Q05655 (PRKCD) | score3 | PhosphoSitePlus Signor | 11877440 | |
| S1227 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus UniProt | 9819408, 23186163 | ||
| S1227 | Phosphorylation | P49841 (GSK3B) | score3 | neXtProt PhosphoSitePlus | 9819408 | |
| Y1229 | Phosphorylation | score4 | IntAct neXtProt phospho.ELM PhosphoSitePlus Signor UniProt | 14521915, 14766232, 12750561, ... | ||
| Y1229 | Phosphorylation | P00533 (EGFR) | score3 | phospho.ELM Signor | 11483589 | |
| Y1229 | Phosphorylation | P06239 (LCK) | score3 | neXtProt Signor | 14766232 | |
| Y1229 | Phosphorylation | P07948 (LYN) | score2 | neXtProt | 12750561 | |
| Y1229 | Phosphorylation | P12931 (SRC) | score4 | neXtProt phospho.ELM PhosphoSitePlus Signor | 17545600, 11152665 | |
| S1233 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1240 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1242 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1243 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 18083107, 14521915, 16888623, ... | ||
| Y1243 | Phosphorylation | A0A173G4P4 (Abl fusion) | score2 | phospho.ELM | 16888623 | |
| Y1243 | Phosphorylation | P00519 (ABL1) | score1 | Signor | 16888623 | |
| T1244 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S62 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y139 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y151 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y157 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y160 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y177 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y191 | Phosphorylation | score0 | HPRD | 18083107 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y200 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y212 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y218 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y221 | Phosphorylation | score0 | HPRD | 18083107 | ||
| T233 | Phosphorylation | score1 | HPRD | 11877440 | ||
| T233 | Phosphorylation | Q05655 (PRKCD) | score1 | HPRD | 11877440 | |
| S236 | Phosphorylation | score1 | HPRD | 9819408 | ||
| S236 | Phosphorylation | P49841 (GSK3B) | score1 | HPRD | 9819408 | |
| Y238 | Phosphorylation | score2 | HPRD | 11152665, 14766232, 11483589 | ||
| Y238 | Phosphorylation | P00533 (EGFR) | score2 | HPRD | 11152665, 11483589 | |
| Y238 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 14766232 | |
| Y252 | Phosphorylation | score2 | HPRD | 7664271, 15471854 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y95 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y107 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y113 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y116 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y133 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y147 | Phosphorylation | score0 | HPRD | 18083107 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S38 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S47 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T60 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S62 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y204 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y191 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y203 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y209 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y212 | Phosphorylation | score0 | HPRD | 18083107 | ||
| T224 | Phosphorylation | score1 | HPRD | 11877440 | ||
| T224 | Phosphorylation | Q05655 (PRKCD) | score1 | HPRD | 11877440 | |
| S227 | Phosphorylation | score1 | HPRD | 9819408 | ||
| S227 | Phosphorylation | P49841 (GSK3B) | score1 | HPRD | 9819408 | |
| Y229 | Phosphorylation | score2 | HPRD | 14766232, 11152665, 11483589 | ||
| Y229 | Phosphorylation | P00533 (EGFR) | score2 | HPRD | 11152665, 11483589 | |
| Y229 | Phosphorylation | P43403 (ZAP70) | score1 | HPRD | 14766232 | |
| Y243 | Phosphorylation | score2 | HPRD | 7664271, 15471854 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y209 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y221 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y227 | Phosphorylation | score0 | HPRD | 18083107 | ||
| Y230 | Phosphorylation | score0 | HPRD | 18083107 | ||
| T242 | Phosphorylation | score1 | HPRD | 11877440 | ||
| T242 | Phosphorylation | Q05655 (PRKCD) | score1 | HPRD | 11877440 | |
| S245 | Phosphorylation | score1 | HPRD | 9819408 | ||
| S245 | Phosphorylation | P49841 (GSK3B) | score1 | HPRD | 9819408 | |
| Y247 | Phosphorylation | score1 | HPRD | 11483589 | ||
| Y247 | Phosphorylation | P00533 (EGFR) | score1 | HPRD | 11483589 | |
| Y261 | Phosphorylation | score1 | HPRD | 7664271 |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q05655 (PRKCD) | T507 | P15941 (MUC1) | increased_association | eFIP | 28692035 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S47 | G47 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S47 | R47 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| Y113 | * | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y116 | F116 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| Y157 | * | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y160 | F160 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| Y209 | * | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y212 | F212 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| Y218 | * | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y221 | F221 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| Y227 | * | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| Y230 | F230 | Biomuta | DOID:263 / kidney cancer [ cosmic ] |
