iPTMnet Report for P15923 (TCF3)
Protein Information
UniProt AC / UniProt ID | P15923 / TFE2_HUMAN |
Protein Name | Transcription factor E2-alpha |
Gene Name | Name: TCF3 Synonyms:BHLHB21,E2A,ITF1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P15923 |
PRO Name | transcription factor E2-alpha (human) |
Definition | A transcription factor E2-alpha that is encoded in the genome of human. |
Short Label | hTCF3 |
Category | organism-gene |
P15923 (TCF3) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T12 | Phosphorylation | score1 | PhosphoSitePlus | |||
K34 | Acetylation | score1 | PhosphoSitePlus | |||
S39 | Phosphorylation | Q9P286 (PAK5) | score3 | PhosphoSitePlus RLIMS-P | 26212009 | |
S48 | Phosphorylation | score2 | neXtProt | 11114297 | ||
R105 | Methylation | score1 | PhosphoSitePlus | |||
Y108 | Phosphorylation | score1 | PhosphoSitePlus | |||
S110 | Phosphorylation | score1 | PhosphoSitePlus | |||
S134 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
S139 | Phosphorylation | Q16539 (MAPK14) , Q15759 (MAPK11) , P11802 (CDK4) , P24941 (CDK2) | score4 | neXtProt PRO PhosphoSitePlus Signor UniProt | 15719023, 11114297, 19690332 | |
S141 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y149 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y150 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y153 | Phosphorylation | score1 | PhosphoSitePlus | |||
S156 | Phosphorylation | score1 | PhosphoSitePlus | |||
K171 | Acetylation | score1 | PhosphoSitePlus | |||
S245 | Phosphorylation | P11802 (CDK4) , P24941 (CDK2) | score3 | neXtProt PhosphoSitePlus | 11114297 | |
S341 | Phosphorylation | Q02779 (MAP3K10) | score3 | PhosphoSitePlus Signor | 19801649 | |
S345 | Phosphorylation | score1 | PhosphoSitePlus | |||
S346 | Phosphorylation | score1 | PhosphoSitePlus | |||
S350 | Phosphorylation | score1 | PhosphoSitePlus | |||
S351 | Phosphorylation | score1 | PhosphoSitePlus | |||
S352 | Phosphorylation | Q02779 (MAP3K10) | score3 | PhosphoSitePlus Signor | 19801649 | |
S354 | Phosphorylation | score1 | PhosphoSitePlus | |||
T355 | Phosphorylation | Q02779 (MAP3K10) | score4 | phospho.ELM PhosphoSitePlus Signor | 14592976, 19801649 | |
S359 | Phosphorylation | Q02779 (MAP3K10) | score4 | PhosphoSitePlus Signor UniProt | 19690332, 19801649 | |
T366 | Phosphorylation | score1 | PhosphoSitePlus | |||
S367 | Phosphorylation | score1 | PhosphoSitePlus | |||
R371 | Methylation | score1 | PhosphoSitePlus | |||
S379 | Phosphorylation | Q02779 (MAP3K10) | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 18669648, 23186163, 19801649 | |
S381 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
Y382 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
K392 | Sumoylation | score1 | PhosphoSitePlus | |||
T411 | Phosphorylation | score1 | PhosphoSitePlus | |||
K498 | Sumoylation | score1 | PhosphoSitePlus | |||
K502 | Sumoylation | score1 | PhosphoSitePlus | |||
S509 | Phosphorylation | score1 | PhosphoSitePlus | |||
S514 | Phosphorylation | score1 | PhosphoSitePlus | |||
T528 | Phosphorylation | score1 | PhosphoSitePlus | |||
S529 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
K570 | Ubiquitination | score1 | PhosphoSitePlus | |||
K584 | Ubiquitination | score1 | PhosphoSitePlus | |||
K614 | Ubiquitination | score1 | PhosphoSitePlus | |||
K625 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S134 | Phosphorylation | score0 | HPRD | 20068231 | ||
S139 | Phosphorylation | score0 | HPRD | 20068231 | ||
S306 | Phosphorylation | score0 | HPRD | 20068231 | ||
T355 | Phosphorylation | P27361 (MAPK3) , P28482 (MAPK1) | score1 | HPRD | 14592976 | |
S379 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 20068231 | ||
S381 | Phosphorylation | score0 | HPRD | 19651622, 18669648, 20068231 | ||
Y382 | Phosphorylation | score0 | HPRD | 18669648 | ||
S514 | Phosphorylation | score0 | HPRD | 19651622 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y149 | Phosphorylation | score1 | PhosphoSitePlus | |||
S352 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt PhosphoSitePlus | 12810726 | |
T355 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt PhosphoSitePlus | 12810726 | |
S359 | Phosphorylation | P28482 (MAPK1) | score3 | neXtProt PhosphoSitePlus | 12810726 | |
S379 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
S381 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
Y382 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
T528 | Phosphorylation | score1 | PhosphoSitePlus | |||
S529 | Phosphorylation | score1 | PhosphoSitePlus | |||
S530 | Phosphorylation | score1 | PhosphoSitePlus | |||
T531 | Phosphorylation | score1 | PhosphoSitePlus | |||
S536 | Phosphorylation | score1 | PhosphoSitePlus | |||
S579 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P17542 (TAL1) | S172 | P15923 (TCF3) | unknown | eFIP | 9111058 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
R105 | Q105 | Biomuta | DOID:3963 / thyroid carcinoma [ cosmic, icgc, tcga ] | |
Y108 | H108 | Biomuta | DOID:3963 / thyroid carcinoma [ cosmic, icgc ] | |
S134 | N134 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc, tcga ] | |
Y153 | C153 | Biomuta | DOID:1909 / melanoma [ cosmic ] | |
S359 | F359 | Biomuta | DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ] | |
R371 | * | Biomuta | DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ] | |
K502 | * | Biomuta | DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ] | |
K614 | T614 | Biomuta | DOID:363 / uterine cancer [ tcga ] |