iPTMnet Report for P15884 (TCF4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15884 / ITF2_HUMAN
Protein Name Transcription factor 4
Gene Name Name: TCF4
Synonyms:BHLHB19,ITF2,SEF2;
Organism Homo sapiens (Human)

PRO ID PR:P15884
DAG View
PRO Name transcription factor 4 (human)
Definition A transcription factor 4 that is encoded in the genome of human.
Short Label hTCF4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15884 (TCF4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation phospho.ELM   PhosphoSitePlus 11711551
S55 Phosphorylation phospho.ELM   PhosphoSitePlus 11711551
S56 Phosphorylation phospho.ELM   PhosphoSitePlus 11711551
S66 Phosphorylation PhosphoSitePlus   UniProt 23186163
S68 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus   UniProt 23186163
S92 Phosphorylation PhosphoSitePlus   UniProt 23186163
R106 Methylation PhosphoSitePlus
Y149 Phosphorylation PhosphoSitePlus
T297 Phosphorylation PhosphoSitePlus
N301 N-Glycosylation GlyGen 29671580
S318 Phosphorylation PhosphoSitePlus
T320 Phosphorylation PhosphoSitePlus
S372 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
Y375 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus   UniProt 21406692
T554 Phosphorylation PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S481 Phosphorylation HPRD 19651622
Site PTM Type PTM Enzyme Score Source PMID
T487 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S383 Phosphorylation PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
T398 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S481 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S66 R66 Biomuta DOID:3571 / liver cancer [ icgc ]
S92 T92 Biomuta DOID:1909 / melanoma [ tcga ]
T320 N320 Biomuta DOID:3571 / liver cancer [ icgc ]
S515 P515 Biomuta DOID:1909 / melanoma [ tcga ]
S515 F515 Biomuta DOID:1909 / melanoma [ icgc, tcga ]