iPTMnet Report for P15692 (VEGFA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15692 / VEGFA_HUMAN
Protein Name Vascular endothelial growth factor A, long form precursor
Gene Name Name: VEGFA
Synonyms:VEGF;
Organism Homo sapiens (Human)

PRO ID PR:P15692
DAG View
PRO Name vascular endothelial growth factor A (human)
Definition A vascular endothelial growth factor A that is encoded in the genome of human.
Short Label hVEGFA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15692 (VEGFA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S77 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
K322 Acetylation PhosphoSitePlus
K327 Acetylation PhosphoSitePlus
K329 Acetylation PhosphoSitePlus
K332 Acetylation PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P40763 (STAT3) S727 P15692 (VEGFA) unknown eFIP 22696236
Phosphorylation Q00987 (MDM2) S166 P15692 (VEGFA) unknown eFIP 27591897


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036631 (hNRP1/iso:1/ClvOGlyco:1) increased Interaction PR:P15692-4 (hVEGFA/iso:VEGF165) PRO 16763549
PR:000036632 (hNRP1/iso:1/ClvOGlyco:2) increased Interaction PR:P15692-4 (hVEGFA/iso:VEGF165) PRO 16763549
PR:000036635 (hNRP1/iso:1/SigPep-) Interaction PR:P15692-4 (hVEGFA/iso:VEGF165) PRO 16763549
PR:000036635 (hNRP1/iso:1/SigPep-) Interaction PR:P15692-4 (hVEGFA/iso:VEGF165) PRO 11986311


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S77 N77 Biomuta DOID:1324 / lung cancer [ cosmic ]
S77 I77 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K329 E329 Biomuta DOID:4606 / bile duct cancer [ cosmic ]