iPTMnet Report for P15586 (GNS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15586 / GNS_HUMAN
Protein Name N-acetylglucosamine-6-sulfatase precursor
Gene Name Name: GNS
Organism Homo sapiens (Human)

PRO ID PR:P15586
DAG View
PRO Name N-acetylglucosamine-6-sulfatase (human)
Definition An N-acetylglucosamine-6-sulfatase that is encoded in the genome of human.
Short Label hGNS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15586 (GNS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C22 Methylation IEDB 31844290
N48 N-Glycosylation GlyGen 24190977
T65 Phosphorylation PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
N106 N-Glycosylation GlyGen 24190977
N111 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N112 N-Glycosylation GlyGen 24190977
N117 N-Glycosylation GlyGen 23090970, 24190977
K125 Ubiquitination PhosphoSitePlus
N178 N-Glycosylation GlyGen 24190977
N183 N-Glycosylation GlyGen   IEDB   UniProt 34089345, 19159218, 24190977, ...23090970, 29741879, 12754519, 27550523
N198 N-Glycosylation GlyGen 24190977
N210 N-Glycosylation GlyGen 24190977
R255 Methylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
T275 O-Glycosylation GlyGen 23301498, 33214551, 34725712, ...30059200, 34019948, 32119511, 28657654
T278 O-Glycosylation GlyGen 23301498, 33214551, 34725712, ...30059200, 34019948, 32119511, 28657654
N279 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 12754519, ...24190977
N317 N-Glycosylation GlyGen   UniProt 34089345, 29741879, 19159218, ...23345538
N362 N-Glycosylation GlyGen 23090970, 29741879, 24190977, ...23345538, 34089345
N387 N-Glycosylation GlyGen   UniProt 34089345, 29741879, 19159218
S404 O-Glycosylation GlyGen 23301498, 33214551, 34725712, ...30059200, 34019948, 32119511, 28657654
N405 N-Glycosylation GlyGen 23090970, 29741879, 24190977, ...34089345
T407 O-Glycosylation GlyGen 22661428
Y416 Phosphorylation PhosphoSitePlus
N422 N-Glycosylation GlyGen   UniProt 1463457, 19159218, 29741879
K502 Ubiquitination PhosphoSitePlus
Y505 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
N317 N-Glycosylation PRO 23345538
N362 N-Glycosylation PRO 23345538


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N111 K111 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K125 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R255 I255 Biomuta DOID:363 / uterine cancer [ icgc ]
K257 N257 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N362 T362 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]