Protein Information

Cytoscape View


UniProt AC / UniProt ID P15586 / GNS_HUMAN
Protein Name N-acetylglucosamine-6-sulfatase precursor
Gene Name Name: GNS
Organism Homo sapiens (Human)

PRO ID PR:P15586
DAG View
PRO Name N-acetylglucosamine-6-sulfatase (human)
Definition An N-acetylglucosamine-6-sulfatase that is encoded in the genome of human.
Short Label hGNS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15586 (GNS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N48 N-Glycosylation GlyGen 24190977
T65 Phosphorylation PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
N106 N-Glycosylation GlyGen 24190977
N111 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N112 N-Glycosylation GlyGen 24190977
N117 N-Glycosylation GlyGen 23090970, 24190977
K125 Ubiquitination PhosphoSitePlus
N178 N-Glycosylation GlyGen 24190977
N183 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 12754519, ...19159218, 24190977
N198 N-Glycosylation GlyGen 24190977
N210 N-Glycosylation GlyGen 24190977
R255 Methylation PhosphoSitePlus
K257 Ubiquitination PhosphoSitePlus
T275 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...30059200
T278 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...30059200
N279 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 12754519, ...24190977
N317 N-Glycosylation GlyGen   UniProt 29741879, 19159218, 23345538
N362 N-Glycosylation GlyGen 23090970, 29741879, 23345538, ...24190977
N387 N-Glycosylation GlyGen   UniProt 29741879, 19159218
S404 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...30059200
N405 N-Glycosylation GlyGen 23090970, 29741879, 24190977
Y416 Phosphorylation PhosphoSitePlus
N422 N-Glycosylation GlyGen   UniProt 1463457, 19159218, 29741879
K502 Ubiquitination PhosphoSitePlus
Y505 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus   UniProt 23186163


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N111 K111 Biomuta DOID:10534 / stomach cancer [ tcga ]
R255 I255 Biomuta DOID:363 / uterine cancer [ tcga ]
K257 N257 Biomuta DOID:1324 / lung cancer [ tcga ]
T275 N275 Biomuta DOID:3571 / liver cancer [ icgc ]
N317 K317 Biomuta DOID:3571 / liver cancer [ icgc ]
N387 Y387 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
K502 N502 Biomuta DOID:3571 / liver cancer [ icgc ]