iPTMnet Report for P15531 (NME1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15531 / NDKA_HUMAN
Protein Name Nucleoside diphosphate kinase A
Gene Name Name: NME1
Synonyms:NDPKA,NM23;
Organism Homo sapiens (Human)

PRO ID PR:P15531
DAG View
PRO Name nucleoside diphosphate kinase A (human)
Definition A nucleoside diphosphate kinase A that is encoded in the genome of human.
Short Label hNME1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15531 (NME1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R6 Methylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
R18 Methylation PhosphoSitePlus
K26 Acetylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
S44 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor 8245015, 8810265
S44 Phosphorylation P15531 (NME1) PhosphoSitePlus   Signor 8245015
K49 Acetylation PhosphoSitePlus
K49 Sumoylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
K56 Acetylation PhosphoSitePlus
K56 Sumoylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
R58 Methylation PhosphoSitePlus
K66 Acetylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
R88 Methylation PhosphoSitePlus
T94 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18234856
T94 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
S99 Phosphorylation PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
K100 Methylation PhosphoSitePlus
K100 Sumoylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus
H118 Phosphorylation PhosphoSitePlus 21121676, 22869372, 17155928, ...12859952
H118 Phosphorylation P15531 (NME1) PhosphoSitePlus 21121676, 22869372, 17155928, ...12859952
S120 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9038158, 23186163, 17155928, ...18234856, 28831131, 22869372, 8810265
S120 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 18234856
S120 Phosphorylation P15531 (NME1) PhosphoSitePlus 9038158, 17155928
S122 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 16847342, 23186163, 17135357, ...28831131, 22869372, 8810265, 23448979
S122 Phosphorylation Q13131 (PRKAA1) RLIMS-P+ 17135357, 16847342
S125 O-Glycosylation GlyGen 35083852, 34725712, 35138101, ...33465208, 32870666
S125 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23448979, 23186163, 8810265
S144 Phosphorylation RLIMS-P+ 16847342
S144 Phosphorylation Q13131 (PRKAA1) RLIMS-P+ 16847342
Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation HPRD 8245015, 8810265
S44 Phosphorylation P15531 (NME1) HPRD 8245015, 8810265
T94 Phosphorylation HPRD 20166139, 18669648, 20068231
S99 Phosphorylation HPRD 20068231
S120 Phosphorylation HPRD 19651622, 8810265
S120 Phosphorylation P15531 (NME1) HPRD 19651622, 8810265
S122 Phosphorylation HPRD 19651622, 8810265
S122 Phosphorylation P15531 (NME1) HPRD 19651622, 8810265
S125 Phosphorylation HPRD 8810265
S125 Phosphorylation P15531 (NME1) HPRD 8810265
Site PTM Type PTM Enzyme Score Source PMID
S69 Phosphorylation HPRD 8245015, 8810265
S69 Phosphorylation P15531 (NME1) HPRD 8245015, 8810265
T119 Phosphorylation HPRD 20166139, 18669648, 20068231
S124 Phosphorylation HPRD 20068231
S145 Phosphorylation HPRD 19651622, 8810265
S145 Phosphorylation P15531 (NME1) HPRD 19651622, 8810265
S147 Phosphorylation HPRD 19651622, 8810265
S147 Phosphorylation P15531 (NME1) HPRD 19651622, 8810265
S150 Phosphorylation HPRD 8810265
S150 Phosphorylation P15531 (NME1) HPRD 8810265


P15531 (NME1) as PTM Enzyme



Substrate Site Score Source PMID
P15531 (NME1) S44 HPRD   PhosphoSitePlus   Signor 8245015, 8810265
P15531-2 (NME1) S69 HPRD 8245015, 8810265
P15531 (NME1) H118 PhosphoSitePlus 21121676, 22869372, 17155928, ...12859952
P15531 (NME1) S120 HPRD   PhosphoSitePlus 19651622, 9038158, 17155928, ...8810265
P15531-1 (NME1) S122 HPRD 19651622, 8810265
P15531-1 (NME1) S125 HPRD 8810265
P15531-2 (NME1) S145 HPRD 19651622, 8810265
P15531-2 (NME1) S147 HPRD 19651622, 8810265
P15531-2 (NME1) S150 HPRD 8810265
Q8IVT5 (KSR1) S406 Signor 12105213
Q969H4-2 (CNKSR1) S385 HPRD 12105213


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R6 H6 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R18 W18 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K31 E31 Biomuta DOID:1324 / lung cancer [ cosmic ]
R58 H58 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R58 C58 Biomuta DOID:9256 / colorectal cancer [ cosmic ]