iPTMnet Report for P15529 (CD46)
Protein Information
| UniProt AC / UniProt ID | P15529 / MCP_HUMAN |
| Protein Name | Membrane cofactor protein precursor |
| Gene Name | Name: CD46 Synonyms:MCP,MIC10; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P15529 |
| PRO Name | membrane cofactor protein (human) |
| Definition | A membrane cofactor protein that is encoded in the genome of human. |
| Short Label | hCD46 |
| Category | organism-gene |
DAG ViewP15529 (CD46) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K51 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K66 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N83 | N-Glycosylation | score1 | GlyGen | 23090970, 29741879, 24190977 | ||
| T85 | O-Glycosylation | score1 | GlyGen | 33214551, 28510447, 34019948, ... | ||
| K153 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K159 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K167 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K224 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K237 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C256 | Methylation | score1 | IEDB | 31844290 | ||
| N273 | N-Glycosylation | score1 | GlyGen | 29741879 | ||
| T303 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T320 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y321 | Phosphorylation | score2 | UniProt | 10657632 | ||
| S326 | O-Glycosylation | score1 | GlyGen | 25813380 | ||
| D340 | Phosphorylation | score2 | UniProt | 10657632 | ||
| I354 | Phosphorylation | score2 | UniProt | 10657632 | ||
| V355 | Phosphorylation | score2 | UniProt | 10657632 | ||
| L369 | Phosphorylation | score2 | UniProt | 10657632 | ||
| Q370 | Phosphorylation | score2 | UniProt | 10657632 | ||
| K375 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y378 | Phosphorylation | score1 | PhosphoSitePlus | |||
| H384 | Phosphorylation | score2 | UniProt | 10657632 | ||
| K388 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S391 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K314 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y321 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T323 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y324 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K327 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y368 | Phosphorylation | P07947 (YES1) | score1 | HPRD | 11901164 | |
| K377 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y384 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15592455, 19901323 | ||
| T386 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y387 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15592455 | ||
| K390 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y353 | Phosphorylation | P07947 (YES1) | score1 | HPRD | 11901164 | |
| Y369 | Phosphorylation | score0 | HPRD | 15592455, 19901323 | ||
| Y372 | Phosphorylation | score0 | HPRD | 15592455 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y338 | Phosphorylation | P07947 (YES1) | score1 | HPRD | 11901164 | |
| K347 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y354 | Phosphorylation | P12931 (SRC) , P07947 (YES1) | score4 | HPRD neXtProt PhosphoSitePlus | 15592455, 19901323, 11901164 | |
| T356 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y357 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 15592455 | ||
| T359 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K360 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T362 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T363 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T323 | S323 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| T323 | I323 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| Y324 | H324 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| Y343 | H343 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| T356 | I356 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| T356 | S356 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| Y357 | H357 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| Y372 | H372 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| T386 | S386 | Biomuta | DOID:5041 / esophageal cancer [ cosmic, icgc ] | |
| T386 | I386 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| Y387 | H387 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
