Protein Information

Cytoscape View


UniProt AC / UniProt ID P15514 / AREG_HUMAN
Protein Name Amphiregulin precursor
Gene Name Name: AREG
Synonyms:AREGB;
Organism Homo sapiens (Human)

PRO ID PR:P15514
DAG View
PRO Name amphiregulin (human)
Definition An amphiregulin that is encoded in the genome of human.
Short Label hAREG
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15514 (AREG) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S41 O-Glycosylation PhosphoSitePlus
T52 O-Glycosylation PhosphoSitePlus
S53 O-Glycosylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
T169 O-Glycosylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
K230 Acetylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
Y231 Phosphorylation HPRD   PhosphoSitePlus 19664994
K239 Acetylation PhosphoSitePlus
K240 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S41 P41 Biomuta DOID:363 / uterine cancer [ tcga ]
S41 F41 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
K109 N109 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S117 I117 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y231 * Biomuta DOID:3571 / liver cancer [ icgc ]