iPTMnet Report for P15144 (ANPEP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P15144 / AMPN_HUMAN
Protein Name Aminopeptidase N
Gene Name Name: ANPEP
Synonyms:APN,CD13,PEPN;
Organism Homo sapiens (Human)

PRO ID PR:P15144
DAG View
PRO Name aminopeptidase N (human)
Definition An aminopeptidase N that is encoded in the genome of human.
Short Label hANPEP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15144 (ANPEP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y6 Phosphorylation PhosphoSitePlus
N42 N-Glycosylation GlyGen 29741879, 23345538
S43 Phosphorylation PhosphoSitePlus
T56 O-Glycosylation GlyGen 30459171
T57 O-Glycosylation GlyGen 30459171
S61 O-Glycosylation GlyGen 30459171
T63 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
N128 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 29391424, 22932899, 23345538, 29741879, 29671580
Y161 Phosphorylation PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
N234 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 26791533, 29391424, 22932899, 29741879
N265 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 26791533, 15084671, 22932899
N319 N-Glycosylation GlyGen   UniProt 22932899
Y441 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
T457 O-Glycosylation GlyGen 30459171
T457 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
N527 N-Glycosylation GlyGen   UniProt 22932899
N573 N-Glycosylation GlyGen   UniProt 19159218
Y582 Phosphorylation PhosphoSitePlus
T589 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
Y600 Phosphorylation PhosphoSitePlus
N625 N-Glycosylation GlyGen   UniProt 22932899
S670 Phosphorylation PhosphoSitePlus
N681 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...26791533, 29391424, 22932899, 29741879
T727 Phosphorylation PhosphoSitePlus
N735 N-Glycosylation GlyGen 29741879, 29391424
N818 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 22932899, 29741879
Y913 Phosphorylation PhosphoSitePlus
T928 Phosphorylation HPRD   PhosphoSitePlus 17924679
S932 Phosphorylation PhosphoSitePlus
T934 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N42 N-Glycosylation PRO 23345538
N128 N-Glycosylation PRO 29671580, 23345538
N234 N-Glycosylation PRO 26791533
N265 N-Glycosylation PRO 26791533
N681 N-Glycosylation PRO 26791533


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y6 F6 Biomuta DOID:263 / kidney cancer [ cosmic ]
T57 I57 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T57 A57 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S452 F452 Biomuta [ cosmic ]
S460 L460 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
N527 K527 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S590 F590 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y600 * Biomuta DOID:263 / kidney cancer [ cosmic ]
N735 T735 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S932 L932 Biomuta DOID:1612 / breast cancer [ cosmic ]