Protein Information

Cytoscape View


UniProt AC / UniProt ID P15121 / ALDR_HUMAN
Protein Name Aldo-keto reductase family 1 member B1
Gene Name Name: AKR1B1
Synonyms:ALDR1,ALR2;
Organism Homo sapiens (Human)

PRO ID PR:P15121
DAG View
PRO Name aldose reductase (human)
Definition An aldose reductase that is encoded in the genome of human.
Short Label hAKR1B1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P15121 (AKR1B1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 8281941
S3 Phosphorylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
T20 Phosphorylation PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K95 Acetylation PhosphoSitePlus   UniProt 19608861
K95 Ubiquitination PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
K117 Acetylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
T192 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
R218 Methylation PhosphoSitePlus
K222 Acetylation PhosphoSitePlus   UniProt 19608861
K222 Methylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
R233 Methylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K243 Acetylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K263 Acetylation PhosphoSitePlus   UniProt 19608861
K263 Ubiquitination PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
T266 Phosphorylation PhosphoSitePlus
C299 S-Nitrosylation dbSNO 19061876, 19483679, 22178444
C304 S-Nitrosylation dbSNO 19483679
K308 Acetylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 C23 Biomuta DOID:1612 / breast cancer [ icgc ]
Y40 H40 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K69 N69 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K86 R86 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K90 E90 Biomuta DOID:3963 / thyroid carcinoma [ icgc ]
K95 T95 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S98 R98 Biomuta DOID:3571 / liver cancer [ icgc ]
Y104 C104 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T192 N192 Biomuta DOID:3571 / liver cancer [ icgc ]
K240 T240 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S264 F264 Biomuta DOID:1909 / melanoma [ tcga ]