Protein Information

Cytoscape View

UniProt AC / UniProt ID P15104 / GLNA_HUMAN
Protein Name Glutamine synthetase
Gene Name Name: GLUL
Organism Homo sapiens (Human)

PRO ID PR:P15104
DAG View
PRO Name glutamine synthetase (human)
Definition A glutamine synthetase that is encoded in the genome of human.
Short Label hGLUL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P15104 (GLUL) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 19413330
K11 Acetylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
Y17 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K103 Acetylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
C183 S-Nitrosylation dbSNO 24105792
Y185 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
C359 S-Nitrosylation dbSNO 24105792
Y371 Phosphorylation PhosphoSitePlus
K372 Acetylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T2 P2 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K11 R11 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
Y17 C17 Biomuta DOID:363 / uterine cancer [ tcga ]
Y104 * Biomuta DOID:3571 / liver cancer [ icgc ]
K276 N276 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S320 R320 Biomuta DOID:3571 / liver cancer [ icgc ]
S320 N320 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y336 C336 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S343 Y343 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
C359 Y359 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]