iPTMnet Report for P14866 (HNRNPL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P14866 / HNRPL_HUMAN
Protein Name Heterogeneous nuclear ribonucleoprotein L
Gene Name Name: HNRNPL
Synonyms:HNRPL;ORFNames:P/OKcl.14;
Organism Homo sapiens (Human)

PRO ID PR:P14866
DAG View
PRO Name heterogeneous nuclear ribonucleoprotein L (human)
Definition A heterogeneous nuclear ribonucleoprotein L that is encoded in the genome of human.
Short Label hHNRNPL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14866 (HNRNPL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
K34 Methylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
R46 Methylation PhosphoSitePlus
Y47 Phosphorylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
R56 Methylation PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
K59 Sumoylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K62 Sumoylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
T98 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
R107 Methylation PhosphoSitePlus
K136 Sumoylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S188 Phosphorylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
C260 S-Nitrosylation dbSNO 19483679, 26338901
C261 S-Nitrosylation dbSNO 19483679, 26338901
K264 Acetylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
K269 Acetylation PhosphoSitePlus   UniProt 19608861
K269 Ubiquitination PhosphoSitePlus
K277 Sumoylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
Y285 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus   UniProt 21406692
S298 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
K302 Acetylation PhosphoSitePlus
K302 Sumoylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
Y328 Phosphorylation PhosphoSitePlus
Y333 Phosphorylation PhosphoSitePlus
Y340 Phosphorylation PhosphoSitePlus
R343 Methylation PhosphoSitePlus
R344 Methylation PhosphoSitePlus
R354 Methylation PhosphoSitePlus
R358 Methylation PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus   RLIMS-P 23976881, 28520992
Y363 Phosphorylation PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
S381 Phosphorylation PhosphoSitePlus
R398 Methylation PhosphoSitePlus
C404 Methylation IEDB 31844290
K411 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K418 Sumoylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
R434 Methylation PhosphoSitePlus
T437 Phosphorylation PhosphoSitePlus
K448 Acetylation PhosphoSitePlus
C452 S-Nitrosylation dbSNO 19483679
K455 Ubiquitination PhosphoSitePlus
K475 Acetylation PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
T487 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
S531 Phosphorylation PhosphoSitePlus
K533 Ubiquitination PhosphoSitePlus
S536 Phosphorylation PhosphoSitePlus
K538 Sumoylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S544 Phosphorylation PhosphoSitePlus   Signor   UniProt 22570490
S544 Phosphorylation Q16566 (CAMK4) PhosphoSitePlus   Signor 22570490
K552 Acetylation PhosphoSitePlus
K552 Sumoylation PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
Y565 Phosphorylation PhosphoSitePlus
K568 Sumoylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
Y574 Phosphorylation PhosphoSitePlus
Y576 Phosphorylation PhosphoSitePlus
T577 Phosphorylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
C581 S-Nitrosylation dbSNO 20140087, 22178444
S589 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S52 Phosphorylation HPRD 19413330, 18669648, 20068231
T63 Phosphorylation HPRD 17287340
T98 Phosphorylation HPRD 19651622
S101 Phosphorylation HPRD 19651622, 20068231
S185 Phosphorylation HPRD 19651622, 20068231, 18452278
T282 Phosphorylation HPRD 18452278
Y285 Phosphorylation HPRD 18452278
S298 Phosphorylation HPRD 18669648, 20068231
S486 Phosphorylation HPRD 20068231
S589 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S52 Phosphorylation HPRD 19651622, 20068231, 18452278
T149 Phosphorylation HPRD 18452278
Y152 Phosphorylation HPRD 18452278
S165 Phosphorylation HPRD 18669648, 20068231
S353 Phosphorylation HPRD 20068231
S456 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R107 S107 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K269 N269 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K277 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S291 C291 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S298 N298 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R358 C358 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R398 L398 Biomuta DOID:1324 / lung cancer [ cosmic ]
R398 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R398 Q398 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic ]
K411 T411 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R434 Q434 Biomuta DOID:4159 / skin cancer [ cosmic ]
T437 I437 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K455 R455 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T487 I487 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S536 L536 Biomuta DOID:4159 / skin cancer [ cosmic ]
K552 R552 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]