iPTMnet Report for P14635 (CCNB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P14635 / CCNB1_HUMAN
Protein Name G2/mitotic-specific cyclin-B1
Gene Name Name: CCNB1
Synonyms:CCNB;
Organism Homo sapiens (Human)

PRO ID PR:P14635
DAG View
PRO Name G2/mitotic-specific cyclin-B1 (human)
Definition A G2/mitotic-specific cyclin-B1 that is encoded in the genome of human.
Short Label hCCNB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14635 (CCNB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation RLIMS-P 23505570
S9 Phosphorylation PhosphoSitePlus   RLIMS-P 23505570
K25 Acetylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
K73 Acetylation PhosphoSitePlus   UniProt 19608861
S95 Phosphorylation PhosphoSitePlus
K111 Sumoylation PhosphoSitePlus
S116 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S126 Phosphorylation P06493 (CDK1) , P28482 (MAPK1) , P53350 (PLK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26960431, 15798220, 11242082, ...12524548, 12447691
S128 Phosphorylation P06493 (CDK1) , P53350 (PLK1) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11242082, 12447691
S133 Phosphorylation P53350 (PLK1) , Q9H4B4 (PLK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25362646, 11242082, 12524548, ...18062778, 12447691, 31387297
S147 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31698699, 25362646, 11242082, ...12524548, 12447691, 22273506
C167 Methylation IEDB 31844290
Y177 Phosphorylation PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
T321 Phosphorylation PhosphoSitePlus   UniProt 18691976
T362 Phosphorylation PhosphoSitePlus
T395 Phosphorylation PhosphoSitePlus
K396 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 18691976
S35 Phosphorylation HPRD 18691976
S69 Phosphorylation HPRD 18691976
S126 Phosphorylation P53350 (PLK1) HPRD   PRO 11242082
S128 Phosphorylation P53350 (PLK1) HPRD   PRO 11242082
S133 Phosphorylation P53350 (PLK1) HPRD   PRO 11242082
S147 Phosphorylation P53350 (PLK1) HPRD   PRO 11242082
T321 Phosphorylation HPRD 18691976


P14635 (CCNB1) as PTM Enzyme



Substrate Site Score Source PMID
Q06413-1 (MEF2C) S396 HPRD 16478538
Q92993-2 (KAT5) S86 HPRD 18669648, 12468530
Q92993-1 (KAT5) S90 HPRD 18669648, 12468530
Q92993-3 (KAT5) S119 HPRD 18669648, 12468530
Q92993-3 (KAT5) S123 HPRD 18669648, 12468530
Q96KB5-1 (PBK) T9 HPRD 19413330, 15541388, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027130 (hCCNB1/Phos:1) pS126,pS128,pS133,pS147 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P06493 (CDK1) Y15 P14635 (CCNB1) decreased_association eFIP 31193763
Phosphorylation P06493 (CDK1) T161 P14635 (CCNB1) decreased_association eFIP 35694267
Phosphorylation P06493 (CDK1) Y15 P14635 (CCNB1) inhibited_association eFIP 33628174


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S116 L116 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S126 F126 Biomuta DOID:4159 / skin cancer [ cosmic ]
K311 T311 Biomuta DOID:363 / uterine cancer [ icgc ]
K411 N411 Biomuta DOID:1319 / brain cancer [ cosmic ]
S413 C413 Biomuta DOID:5041 / esophageal cancer [ cosmic ]