Protein Information

Cytoscape View


UniProt AC / UniProt ID P14618 / KPYM_HUMAN
Protein Name Pyruvate kinase PKM
Gene Name Name: PKM
Synonyms:OIP3,PK2,PK3,PKM2;
Organism Homo sapiens (Human)

PRO ID PR:P14618
DAG View
PRO Name pyruvate kinase PKM (human)
Definition A pyruvate kinase PKM that is encoded in the genome of human.
Short Label hPKM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14618 (PKM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 25944712
S2 Phosphorylation PhosphoSitePlus
K3 Acetylation PhosphoSitePlus
K3 Methylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
S37 Phosphorylation P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 18088087, ...16964243, 27080861, 27340866, 28380434, 31252559, 23178880, 27485204, 18669648, 17287340, 24275569, 27323830, 23186163, 19690332, 20068231, 17081983
T41 Phosphorylation PhosphoSitePlus   UniProt 23186163
T45 Phosphorylation Q96GD4 (AURKB) phospho.ELM   PhosphoSitePlus   RLIMS-P+ 25412762, 17287340
C49 S-Nitrosylation dbSNO 26338901, 22126794
T50 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
T60 Phosphorylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus   UniProt 19608861
K62 Ubiquitination PhosphoSitePlus
K66 Acetylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
Y83 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
T87 Phosphorylation PhosphoSitePlus
K89 Acetylation PhosphoSitePlus   UniProt 19608861
K89 Ubiquitination PhosphoSitePlus
R92 Methylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus   RLIMS-P 27340866
S100 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation Q9UM73 (ALK) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 28418088, 15592455, 26959741, ...23640882, 25541689, 27883057, 22140559, 27385486, 16497976, 23186163, 25263439, 27606486, 23814019, 30809301, 25880801, 29440169, 27384996, 28414323, 25840825, 31252559, 29910687, 30009856, 23837608, 26258887, 28394882, 27602585
K115 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus   UniProt 23186163
T129 Phosphorylation PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
Y148 Phosphorylation P00533 (EGFR) PhosphoSitePlus 26759242
K151 Acetylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
C152 S-Nitrosylation dbSNO 19483679
Y161 Phosphorylation PhosphoSitePlus
K162 Acetylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K166 Acetylation PhosphoSitePlus   UniProt 19608861
K166 Sumoylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
Y175 Phosphorylation PhosphoSitePlus   UniProt 19690332
S182 Phosphorylation PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus   UniProt 19690332
S202 Phosphorylation PhosphoSitePlus   RLIMS-P 27340866
S205 Phosphorylation PhosphoSitePlus
K206 Acetylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K207 Acetylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
K224 Acetylation PhosphoSitePlus
K224 Sumoylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K230 Acetylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
R255 Methylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
K261 Acetylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K266 Acetylation PhosphoSitePlus   UniProt 19608861
K266 Ubiquitination PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
K270 Sumoylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
R278 Methylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
K305 Acetylation PhosphoSitePlus   UniProt 21700219
K305 Ubiquitination PhosphoSitePlus
K311 Acetylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
R319 Methylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
C326 S-Nitrosylation dbSNO 25040305
T328 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 30297868, 29262861
K336 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus   RLIMS-P 26258887
T365 Phosphorylation PhosphoSitePlus   RLIMS-P 26258887
K367 Acetylation PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
Y370 Phosphorylation PhosphoSitePlus
Y390 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455
T405 O-Glycosylation PhosphoSitePlus
S406 O-Glycosylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
T409 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
K422 Acetylation PhosphoSitePlus
C423 S-Nitrosylation dbSNO 19483679, 26338901
C424 S-Nitrosylation dbSNO 19483679, 26338901, 22126794
S425 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
K433 Acetylation PhosphoSitePlus   UniProt 19608861
K433 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
Y444 Phosphorylation PhosphoSitePlus
T454 Phosphorylation Q9P1W9 (PIM2) PhosphoSitePlus   RLIMS-P 24142698, 27045080, 29262861
T459 Phosphorylation PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
R467 Methylation PhosphoSitePlus
C474 S-Nitrosylation dbSNO 19483679, 26338901
K475 Ubiquitination PhosphoSitePlus
K498 Acetylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
R500 Methylation PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
T513 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
T524 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation HPRD 19413330, 18691976, 18088087, ...16964243, 20230923, 18767875, 19664994, 19664995, 19651622, 17322306, 18669648, 20058876, 18707149, 17287340, 19415658, 20068231, 18212344
T45 Phosphorylation HPRD 17287340
S57 Phosphorylation HPRD 20068230
Y105 Phosphorylation HPRD 16497976
T129 Phosphorylation HPRD 20068231
S172 Phosphorylation HPRD 20068231
S287 Phosphorylation HPRD 20068231
T328 Phosphorylation HPRD 17525332
Y390 Phosphorylation HPRD 17016520
T405 Phosphorylation HPRD 20068231
S406 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
K3 Acetylation PhosphoSitePlus
S37 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18088087, 16964243, ...20230923, 18767875, 19664994, 19664995, 19651622, 17322306, 18691976, 18669648, 20058876, 18707149, 17287340, 19415658, 20068231, 18212344
T45 Phosphorylation HPRD 17287340
S57 Phosphorylation HPRD 20068230
Y83 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation HPRD   PhosphoSitePlus 16497976
T129 Phosphorylation HPRD 20068231
K135 Acetylation PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
S172 Phosphorylation HPRD 20068231
K206 Acetylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
S287 Phosphorylation HPRD 20068231
K305 Acetylation PhosphoSitePlus
T328 Phosphorylation HPRD 17525332
T365 Phosphorylation P45983 (MAPK8) PhosphoSitePlus 26258887
Y370 Phosphorylation PhosphoSitePlus
K393 Acetylation PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
Y421 Phosphorylation PhosphoSitePlus
T432 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus


P14618 (PKM) as PTM Enzyme



Substrate Site Score Source PMID
O00161 (SNAP23) S95 RLIMS-P+ 28067230
O43684 (BUB3) Y207 PhosphoSitePlus 24316223
P40763 (STAT3) Y705 PhosphoSitePlus   Signor 22306293


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00161 (SNAP23) S95 P14618 (PKM) unknown eFIP 28067230
Phosphorylation P14618 (PKM) S37 P00533 (EGFR) unknown eFIP 23178880
Phosphorylation P30304 (CDC25A) Y59 P14618 (PKM) unknown eFIP 27485204


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000037192 (hCTNNB1/iso:1/Phos:8) Interaction PR:P14618 (hPKM) PRO 22056988


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:1909 / melanoma [ tcga ]
S6 T6 Biomuta DOID:363 / uterine cancer [ tcga ]
C49 Y49 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T50 N50 Biomuta DOID:3571 / liver cancer [ icgc ]
S55 F55 Biomuta DOID:363 / uterine cancer [ tcga ]
S57 L57 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
T60 M60 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K62 M62 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K89 N89 Biomuta DOID:1324 / lung cancer [ tcga ]
R92 C92 Biomuta DOID:1790 / malignant mesothelioma [ tcga ] DOID:363 / uterine cancer [ tcga ]
Y161 * Biomuta DOID:3571 / liver cancer [ icgc ]
S202 P202 Biomuta DOID:363 / uterine cancer [ tcga ]
K206 R206 Biomuta DOID:363 / uterine cancer [ tcga ]
S222 L222 Biomuta DOID:11934 / head and neck cancer [ tcga ]
K266 N266 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S287 I287 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
R319 L319 Biomuta DOID:11934 / head and neck cancer [ icgc ]
S434 Y434 Biomuta DOID:3571 / liver cancer [ icgc ]
R467 C467 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ tcga ]
K475 M475 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R500 Q500 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T513 I513 Biomuta DOID:4362 / cervical cancer [ tcga ]
S519 F519 Biomuta DOID:1324 / lung cancer [ tcga ]