iPTMnet Report for P14616 (INSRR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P14616 / INSRR_HUMAN
Protein Name Insulin receptor-related protein precursor
Gene Name Name: INSRR
Synonyms:IRR;
Organism Homo sapiens (Human)

PRO ID PR:P14616
DAG View
PRO Name insulin receptor-related protein (human)
Definition An insulin receptor-related protein that is encoded in the genome of human.
Short Label hINSRR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14616 (INSRR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S542 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
T600 Phosphorylation HPRD 18767875
T606 Phosphorylation HPRD 18767875
S613 Phosphorylation HPRD 18767875
T614 Phosphorylation HPRD 18767875
S615 Phosphorylation HPRD 18767875
S618 Phosphorylation HPRD 18767875
S619 Phosphorylation HPRD 18767875
S775 Phosphorylation PhosphoSitePlus
T781 Phosphorylation PhosphoSitePlus
Y783 Phosphorylation PhosphoSitePlus
K821 Sumoylation PhosphoSitePlus
K829 Sumoylation PhosphoSitePlus
Y994 Phosphorylation PhosphoSitePlus
S1124 Phosphorylation PhosphoSitePlus
T1128 Phosphorylation PhosphoSitePlus
K1151 Ubiquitination PhosphoSitePlus
S1271 Phosphorylation PhosphoSitePlus
T1284 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S553 N553 Biomuta DOID:363 / uterine cancer [ icgc ]
T600 K600 Biomuta DOID:3571 / liver cancer [ cosmic ]
T606 M606 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T606 K606 Biomuta DOID:1324 / lung cancer [ cosmic ]
K821 N821 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K829 R829 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K829 T829 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1124 Y1124 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1124 F1124 Biomuta DOID:4159 / skin cancer [ cosmic ]