iPTMnet Report for P14598 (NCF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P14598 / NCF1_HUMAN
Protein Name Neutrophil cytosol factor 1
Gene Name Name: NCF1
Synonyms:NOXO2,SH3PXD1A;
Organism Homo sapiens (Human)

PRO ID PR:P14598
DAG View
PRO Name neutrophil cytosol factor 1 (human)
Definition A neutrophil cytosol factor 1 that is encoded in the genome of human.
Short Label hNCF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14598 (NCF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y41 Phosphorylation PhosphoSitePlus
T45 Phosphorylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 17217339
T133 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus   Signor 17217339
T138 Phosphorylation PhosphoSitePlus 17217339
T138 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 17217339
Y139 Phosphorylation PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus 17217339
T153 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 17217339
S208 Phosphorylation phospho.ELM   PhosphoSitePlus 11535139, 11485312
S208 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 11535139
Y279 Phosphorylation PhosphoSitePlus
S283 Phosphorylation phospho.ELM   PhosphoSitePlus 11535139, 11485312
S283 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 11535139
S288 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 17217339
S288 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus   Signor 17217339
S303 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12056906, 9545283, 8089108, ...8626435, 7520867
S303 Phosphorylation P05771 (PRKCB) neXtProt   PhosphoSitePlus   Signor 12056906
S303 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 12056906, 8626435
S303 Phosphorylation Q05513 (PRKCZ) Signor 12056906
S303 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus   Signor 12056906
S304 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 20920494, 23119229, 35108370, ...12734380, 8626435, 9545283, 10559253, 8089108, 12056906, 7520867, 28240310
S304 Phosphorylation P05771-2 (PRKCB) neXtProt   PhosphoSitePlus   Signor 12056906
S304 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 12056906, 8626435
S304 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 12734380, 10559253
S304 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus   Signor 20920494, 12056906
S304 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus   Signor 12056906
S310 Phosphorylation PhosphoSitePlus   RLIMS-P 8626435
S315 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 35108370, 23119229, 12056906, ...8626435, 23085266
S315 Phosphorylation P05771 (PRKCB) neXtProt   PhosphoSitePlus   Signor 12056906
S315 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 12056906, 8626435
S315 Phosphorylation Q05513 (PRKCZ) Signor 12056906
S315 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus   Signor 12056906
S320 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 35108370, 23119229, 8626435, ...17217339, 8089108, 12056906, 7520867
S320 Phosphorylation P05771-2 (PRKCB) neXtProt   PhosphoSitePlus   Signor 12056906
S320 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 12056906, 8626435
S320 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 8626435
S320 Phosphorylation Q05513 (PRKCZ) Signor 12056906
S320 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus   Signor 12056906
S320 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus   Signor 17217339
S328 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 35108370, 7520867, 31811262, ...23119229, 34068760, 12734380, 28240310, 10559253, 27809835, 30093530, 12056906, 8089108, 8626435, 23085266, 32531347, 28119629, 8226891
S328 Phosphorylation P05771 (PRKCB) neXtProt   PhosphoSitePlus   Signor 12056906
S328 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 12056906, 8626435
S328 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 8626435
S328 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 12734380, 10559253
S328 Phosphorylation Q05513 (PRKCZ) Signor 12056906
S328 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus   Signor 12056906
S345 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25877926, 35108370, 7520867, ...31811262, 23119229, 23975181, 17217339, 27271317, 8626435, 34068760, 35940074, 31736979, 8089108, 15629715, 23085266, 35218706, 16778989, 28119629, 33388549
S345 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus   Signor 8626435, 15629715, 16778989
S345 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 8626435, 16778989
S345 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus 15629715, 16778989
S345 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus   Signor 17217339
S348 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 8626435, 11485312, 17217339, ...8089108, 11535139, 15629715
S348 Phosphorylation P27361 (MAPK3) phospho.ELM   PhosphoSitePlus 8626435, 15629715
S348 Phosphorylation P28482 (MAPK1) neXtProt 8626435
S348 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 11535139
S348 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus 15629715
S348 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 17217339
T356 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 17217339
T356 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus   Signor 17217339
S359 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 8626435, 35940074, 17217339, ...12056906, 9857051, 28119629
S359 Phosphorylation P05771 (PRKCB) neXtProt   PhosphoSitePlus   Signor 12056906
S359 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 12056906, 8626435
S359 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 8626435
S359 Phosphorylation Q05513 (PRKCZ) Signor 12056906
S359 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus   Signor 12056906
S359 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 17217339
S370 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 8626435, 35940074, 17217339, ...12056906, 9857051, 28119629
S370 Phosphorylation P05771-2 (PRKCB) neXtProt   PhosphoSitePlus   Signor 12056906
S370 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 12056906, 8626435
S370 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 8626435
S370 Phosphorylation Q05513 (PRKCZ) Signor 12056906
S370 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus   Signor 12056906
S370 Phosphorylation Q9NWZ3 (IRAK4) PhosphoSitePlus 17217339
S379 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 7520867, 12056906
S379 Phosphorylation P05771-2 (PRKCB) neXtProt   PhosphoSitePlus   Signor 12056906
S379 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 12056906
S379 Phosphorylation Q05513 (PRKCZ) Signor 12056906
S379 Phosphorylation Q05655 (PRKCD) neXtProt   PhosphoSitePlus   Signor 12056906
S381 Phosphorylation PhosphoSitePlus
T382 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048528 (hNCF1/Phos:2) pS303,pS304,pS320,pS328,pS345,pS348 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P14598 (NCF1) S345 Q13526 (PIN1) unknown eFIP 20956805


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y48 C48 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
T138 K138 Biomuta DOID:1324 / lung cancer [ cosmic ]
S208 F208 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]