iPTMnet Report for P14416 (DRD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P14416 / DRD2_HUMAN
Protein Name D(2) dopamine receptor
Gene Name Name: DRD2
Organism Homo sapiens (Human)

PRO ID PR:P14416
DAG View
PRO Name D(2) dopamine receptor (human)
Definition A D(2) dopamine receptor that is encoded in the genome of human.
Short Label hDRD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14416 (DRD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T134 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
T225 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
T318 Phosphorylation RLIMS-P 33859231
S321 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P   Signor 24391960
K324 Methylation PhosphoSitePlus
K332 Methylation PhosphoSitePlus
K336 Methylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T134 Phosphorylation PhosphoSitePlus
T225 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T144 M144 Biomuta DOID:363 / uterine cancer [ tcga ]
S147 N147 Biomuta DOID:363 / uterine cancer [ tcga ]
S148 F148 Biomuta DOID:363 / uterine cancer [ tcga ]
S228 N228 Biomuta DOID:10534 / stomach cancer [ tcga ]
S228 R228 Biomuta DOID:3571 / liver cancer [ icgc ]
S321 R321 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, tcga ]
K336 R336 Biomuta DOID:5041 / esophageal cancer [ icgc ]
S359 G359 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]