iPTMnet Report for P14416 (DRD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P14416 / DRD2_HUMAN
Protein Name D(2) dopamine receptor
Gene Name Name: DRD2
Organism Homo sapiens (Human)

PRO ID PR:P14416
DAG View
PRO Name D(2) dopamine receptor (human)
Definition A D(2) dopamine receptor that is encoded in the genome of human.
Short Label hDRD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14416 (DRD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T134 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
T225 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
T318 Phosphorylation RLIMS-P 33859231
S321 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P   Signor 24391960
K324 Methylation PhosphoSitePlus
K332 Methylation PhosphoSitePlus
K336 Methylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T134 Phosphorylation PhosphoSitePlus
T225 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T144 M144 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S147 N147 Biomuta DOID:363 / uterine cancer [ icgc ]
S148 F148 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S228 N228 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K241 E241 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K241 N241 Biomuta DOID:263 / kidney cancer [ cosmic ]
K258 T258 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T318 P318 Biomuta DOID:4159 / skin cancer [ cosmic ]
S321 R321 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K324 N324 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S325 F325 Biomuta DOID:4159 / skin cancer [ cosmic ]
S354 F354 Biomuta DOID:4159 / skin cancer [ cosmic ]
S359 G359 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]