iPTMnet Report for P14324 (FDPS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P14324 / FPPS_HUMAN
Protein Name Farnesyl pyrophosphate synthase
Gene Name Name: FDPS
Synonyms:FPS,KIAA1293;
Organism Homo sapiens (Human)

PRO ID PR:P14324
DAG View
PRO Name farnesyl pyrophosphate synthase (human)
Definition A farnesyl pyrophosphate synthase that is encoded in the genome of human.
Short Label hFDPS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14324 (FDPS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 O-Glycosylation GlyGen 34019948, 34725712, 33465208
K80 Acetylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
T95 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
K123 Acetylation PhosphoSitePlus   UniProt 19608861
K123 Ubiquitination PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
C204 Methylation IEDB 31844290
K210 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
Y273 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
K353 Acetylation PhosphoSitePlus   UniProt 19608861
K353 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036244 (hFDPS/Ac:1) acM1 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S88 F88 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K112 N112 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y124 C124 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y265 F265 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K332 T332 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S334 N334 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K353 N353 Biomuta DOID:9256 / colorectal cancer [ cosmic ]