iPTMnet Report for P14316 (IRF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P14316 / IRF2_HUMAN
Protein Name Interferon regulatory factor 2
Gene Name Name: IRF2
Organism Homo sapiens (Human)

PRO ID PR:P14316
DAG View
PRO Name interferon regulatory factor 2 (human)
Definition An interferon regulatory factor 2 that is encoded in the genome of human.
Short Label hIRF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14316 (IRF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K29 Acetylation PhosphoSitePlus
K31 Acetylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus   UniProt 12738767
K78 Acetylation PhosphoSitePlus   UniProt 12738767
K78 Sumoylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
K137 Sumoylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
T164 Phosphorylation PhosphoSitePlus
K166 Sumoylation PhosphoSitePlus
C200 Methylation IEDB 31844290
S225 Phosphorylation PhosphoSitePlus   UniProt 24275569
S241 Phosphorylation PhosphoSitePlus
K260 Sumoylation PhosphoSitePlus
K293 Sumoylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K75 Acetylation PRO 12738767
K78 Acetylation PRO 12738767
S143 Phosphorylation HPRD 19413330
S144 Phosphorylation HPRD 19413330
S148 Phosphorylation HPRD 19413330
T162 Phosphorylation HPRD 19413330
S163 Phosphorylation HPRD 19413330
T164 Phosphorylation HPRD 19413330


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028813 (hIRF2/iso:1/Ac:1) acK75,acK78 PRO 12738767


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K137 * Biomuta DOID:3571 / liver cancer [ cosmic ]
K137 Q137 Biomuta DOID:3571 / liver cancer [ cosmic ]
S144 C144 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T162 A162 Biomuta DOID:1324 / lung cancer [ cosmic ]
S163 L163 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C200 R200 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
C200 Y200 Biomuta DOID:1319 / brain cancer [ icgc ]
S225 F225 Biomuta DOID:4159 / skin cancer [ cosmic ]
S333 N333 Biomuta [ cosmic ]