iPTMnet Report for P14136 (GFAP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P14136 / GFAP_HUMAN
Protein Name Glial fibrillary acidic protein
Gene Name Name: GFAP
Organism Homo sapiens (Human)

PRO ID PR:P14136
DAG View
PRO Name glial fibrillary acidic protein (human)
Definition A glial fibrillary acidic protein that is encoded in the genome of human.
Short Label hGFAP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P14136 (GFAP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation Q96GD4 (AURKB) , P17612 (PRKACA) , Q13464 (ROCK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 9832553, 12177195, 11918673, ...9099667, 12686604
S8 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 8439181, 9832553, 12177195, ...11918673, 19170683, 12686604, 7822264, 1379174
R11 Methylation PhosphoSitePlus
R12 Methylation PhosphoSitePlus
S13 Phosphorylation Q13464 (ROCK1) , P17612 (PRKACA) , Q96GD4 (AURKB) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 9832553, 12177195, 11918673, ...9099667, 2155236, 19170683, 24749759, 12686604
Y14 Phosphorylation PhosphoSitePlus
S17 Phosphorylation phospho.ELM   PhosphoSitePlus 7822264, 2155236, 12177195
S38 Phosphorylation Q96GD4 (AURKB) , Q13464 (ROCK1) , P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 9832553, 12177195, 9099667, ...2155236, 7822264, 12686604
K95 Acetylation PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
T150 Phosphorylation PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
K189 Acetylation PhosphoSitePlus
K228 Acetylation PhosphoSitePlus
T240 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
K260 Acetylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
Y324 Phosphorylation PhosphoSitePlus
K339 Acetylation PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
T383 O-Glycosylation GlyGen 30379171, 28657654, 30397120
Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation Q13464 (ROCK1) HPRD 9099667
S8 Phosphorylation P06493 (CDK1) HPRD 7822264, 12177195
S13 Phosphorylation Q13464 (ROCK1) , P17612 (PRKACA) , Q9UQM7 (CAMK2A) , P17252 (PRKCA) HPRD 7822264, 9099667, 2155236, ...2114109
S17 Phosphorylation P17612 (PRKACA) , Q13464 (ROCK1) , Q9UQM7 (CAMK2A) , P17252 (PRKCA) HPRD 7822264, 2155236, 2114109
S38 Phosphorylation P17252 (PRKCA) , Q13464 (ROCK1) , Q9UQM7 (CAMK2A) , P17612 (PRKACA) HPRD 7822264, 2155236, 2114109
S393 Phosphorylation Q9UQM7 (CAMK2A) HPRD 7822264, 2114109
Site PTM Type PTM Enzyme Score Source PMID
S397 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S38 F38 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y116 C116 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
T240 M240 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y242 H242 Biomuta DOID:1324 / lung cancer [ cosmic ]
S305 A305 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y324 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K339 R339 Biomuta DOID:10283 / prostate cancer [ cosmic ]