iPTMnet Report for P13995 (MTHFD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P13995 / MTDC_HUMAN
Protein Name Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor
Gene Name Name: MTHFD2
Synonyms:NMDMC;
Organism Homo sapiens (Human)

PRO ID PR:P13995
DAG View
PRO Name bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (human)
Definition A bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial that is encoded in the genome of human.
Short Label hMTHFD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13995 (MTHFD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K44 Acetylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus   UniProt 19608861
K50 Ubiquitination PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
R143 Methylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K152 Acetylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
T187 Phosphorylation PhosphoSitePlus
T191 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
K329 Acetylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K119 Q119 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K194 N194 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]