iPTMnet Report for P13807 (GYS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P13807 / GYS1_HUMAN
Protein Name Glycogen [starch] synthase, muscle
Gene Name Name: GYS1
Synonyms:GYS;
Organism Homo sapiens (Human)

PRO ID PR:P13807
DAG View
PRO Name glycogen [starch] synthase, muscle (human)
Definition A glycogen [starch] synthase, muscle that is encoded in the genome of human.
Short Label hGYS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13807 (GYS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
T6 Phosphorylation PhosphoSitePlus
S8 Phosphorylation neXtProt   PhosphoSitePlus 2498326
S10 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
T75 Phosphorylation PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
T90 O-Glycosylation GlyGen 31492838, 28510447, 35138101, ...34019948
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
C251 Methylation IEDB 31844290
K271 Ubiquitination PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
Y405 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K418 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
C564 Methylation IEDB 31844290
C575 Methylation IEDB 31844290
K599 Ubiquitination PhosphoSitePlus
Y604 Phosphorylation PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
Y634 Phosphorylation PhosphoSitePlus
Y636 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S641 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15791206, 6772446, 16275910, ...18669648, 14593110
S641 Phosphorylation P49840 (GSK3A) Signor 14593110
S641 Phosphorylation P49841 (GSK3B) neXtProt   Signor 15791206, 14593110
S641 Phosphorylation Q92630 (DYRK2) neXtProt 14593110
S641 Phosphorylation Q96RG2 (PASK) neXtProt 16275910
S645 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15791206, 14680475, ...6772446
S645 Phosphorylation P49841 (GSK3B) neXtProt   PhosphoSitePlus 14680475, 15791206
S645 Phosphorylation Q15759 (MAPK11) neXtProt   PhosphoSitePlus 14680475
S647 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S649 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 6772446
S652 Phosphorylation PhosphoSitePlus
S653 Phosphorylation neXtProt   PhosphoSitePlus 14680475
S653 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 14680475
S653 Phosphorylation Q15759 (MAPK11) neXtProt   PhosphoSitePlus 14680475
S657 Phosphorylation PhosphoSitePlus
Y675 Phosphorylation PhosphoSitePlus
K683 Ubiquitination PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
T700 Phosphorylation PhosphoSitePlus   UniProt 24275569
S710 Phosphorylation PhosphoSitePlus   UniProt 23186163
T713 Phosphorylation PhosphoSitePlus
T715 Phosphorylation PhosphoSitePlus
S716 Phosphorylation PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
S718 Phosphorylation PhosphoSitePlus
T721 Phosphorylation neXtProt   PhosphoSitePlus 14680475
T721 Phosphorylation Q15759 (MAPK11) neXtProt   PhosphoSitePlus 14680475
S723 Phosphorylation PhosphoSitePlus
S727 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 23186163, 19690332, 14680475
S727 Phosphorylation Q15759 (MAPK11) neXtProt   PhosphoSitePlus 14680475
T729 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 2117608
S8 Phosphorylation P17612 (PRKACA) HPRD 2117608
S10 Phosphorylation HPRD 2117608
S10 Phosphorylation P68400 (CSNK2A1) HPRD 2117608
S412 Phosphorylation HPRD 19413330
Y636 Phosphorylation HPRD 18669648
S641 Phosphorylation HPRD 11427888, 18669648, 6772446
S641 Phosphorylation P49841 (GSK3B) HPRD 11427888, 18669648, 6772446
S645 Phosphorylation HPRD 11427888, 18669648, 19664994, ...18691976, 6772446
S645 Phosphorylation P49841 (GSK3B) HPRD 11427888, 18669648, 19664994, ...18691976, 6772446
S647 Phosphorylation HPRD 2117608, 18669648
S647 Phosphorylation P68400 (CSNK2A1) HPRD 2117608, 18669648
S649 Phosphorylation HPRD 11427888, 18669648, 6772446
S649 Phosphorylation P49841 (GSK3B) HPRD 11427888, 18669648, 6772446
S652 Phosphorylation HPRD 19651622, 2117608
S652 Phosphorylation P68400 (CSNK2A1) HPRD 19651622, 2117608
S653 Phosphorylation HPRD 19651622, 2117608
S653 Phosphorylation P49841 (GSK3B) HPRD 19651622, 2117608
S653 Phosphorylation P68400 (CSNK2A1) HPRD 19651622, 2117608
S657 Phosphorylation HPRD 19651622
S698 Phosphorylation HPRD 2117608, 20068231
S698 Phosphorylation P68400 (CSNK2A1) HPRD 2117608, 20068231
T700 Phosphorylation HPRD 20068231
S701 Phosphorylation HPRD 2117608, 20068231
S701 Phosphorylation P68400 (CSNK2A1) HPRD 2117608, 20068231
S702 Phosphorylation HPRD 20068231
S704 Phosphorylation HPRD 20068231
S710 Phosphorylation HPRD 19413330, 18691976, 2117608
S710 Phosphorylation P17612 (PRKACA) HPRD 19413330, 18691976, 2117608
T713 Phosphorylation HPRD 2117608
T713 Phosphorylation P68400 (CSNK2A1) HPRD 2117608
T715 Phosphorylation HPRD 17081983
S716 Phosphorylation HPRD 17081983
S717 Phosphorylation HPRD 17081983
S718 Phosphorylation HPRD 17081983
S720 Phosphorylation HPRD 17081983
S727 Phosphorylation HPRD 19413330, 18691976, 17081983, ...20068231
T729 Phosphorylation HPRD 19413330, 18691976, 17081983
S730 Phosphorylation HPRD 19413330, 17081983
S731 Phosphorylation HPRD 19413330, 18691976, 17081983


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047663 (hGYS1/PhosSer+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T84 S84 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
K286 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K403 T403 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T426 N426 Biomuta DOID:363 / uterine cancer [ icgc ]
K599 E599 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y604 C604 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K615 N615 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
Y636 C636 Biomuta DOID:4159 / skin cancer [ cosmic ]
S647 L647 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
S653 C653 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S698 F698 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T713 M713 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S720 G720 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]