iPTMnet Report for P13796 (LCP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P13796 / PLSL_HUMAN
Protein Name Plastin-2
Gene Name Name: LCP1
Synonyms:PLS2;
Organism Homo sapiens (Human)

PRO ID PR:P13796
DAG View
PRO Name plastin-2 (human)
Definition A plastin-2 that is encoded in the genome of human.
Short Label hLCP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13796 (LCP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17294403, 21406692, 33618712, ...23186163, 26631483, 29882856, 16636079, 24236012, 19799649, 23001012, 27551545, 10446213, 9689080, 24438191, 22581862, 32859369, 30248139, 30244178, 20169155
S5 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 16636079, 10446213
S5 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus 26631483
S5 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus 20169155, 19799649
S5 Phosphorylation Q15418 (RPS6KA1) PhosphoSitePlus 26631483
S7 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 30248139, 19690332, 10446213
K20 Acetylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
Y28 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 19690332
S30 Phosphorylation PhosphoSitePlus   UniProt 19690332
K39 Ubiquitination PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
T54 Phosphorylation PhosphoSitePlus
K76 Acetylation PhosphoSitePlus   UniProt 19608861
K76 Ubiquitination PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K88 Acetylation PhosphoSitePlus   UniProt 19608861
K88 Ubiquitination PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
F90 Methylation IEDB 32357974
K97 Ubiquitination PhosphoSitePlus
C101 Methylation IEDB 31844290
T106 O-Glycosylation GlyGen 35132862, 32870666, 29351928
S107 O-Glycosylation GlyGen 35132862, 32870666, 29351928
S110 O-Glycosylation GlyGen 35132862, 32870666, 29351928
S110 Phosphorylation PhosphoSitePlus
S111 O-Glycosylation GlyGen 35132862, 32870666, 29351928
T114 O-Glycosylation GlyGen 35132862, 32870666, 29351928
T114 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus
S119 O-Glycosylation GlyGen 35132862, 32870666, 29351928
S119 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus   UniProt 15592455
K132 Ubiquitination PhosphoSitePlus
C140 Methylation IEDB 31844290
K165 Ubiquitination PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
K263 Ubiquitination PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
Y276 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
C283 Methylation IEDB 31844290
K285 Ubiquitination PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus   UniProt 23186163
T291 Phosphorylation PhosphoSitePlus   UniProt 23186163
K294 Acetylation PhosphoSitePlus   UniProt 19608861
K294 Ubiquitination PhosphoSitePlus
K297 Acetylation PhosphoSitePlus   UniProt 19608861
K297 Ubiquitination PhosphoSitePlus
Y299 Phosphorylation PhosphoSitePlus
Y300 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus   UniProt 19690332
T351 Phosphorylation PhosphoSitePlus
T353 Phosphorylation PhosphoSitePlus   UniProt 23186163
K361 Acetylation PhosphoSitePlus   UniProt 19608861
K361 Ubiquitination PhosphoSitePlus
Y374 Phosphorylation PhosphoSitePlus
K379 Acetylation PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
T399 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y417 Phosphorylation PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K434 Methylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K444 Methylation PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K455 Acetylation PhosphoSitePlus
K456 Acetylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
K472 Acetylation PhosphoSitePlus   UniProt 19608861
K472 Ubiquitination PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus   UniProt 23186163
K542 Acetylation PhosphoSitePlus   UniProt 19608861
K542 Ubiquitination PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
T548 O-Glycosylation GlyGen 35132862, 32870666, 29351928
T548 Phosphorylation PhosphoSitePlus
S549 O-Glycosylation GlyGen 35132862, 32870666, 29351928
S549 Phosphorylation PhosphoSitePlus
K579 Acetylation PhosphoSitePlus   UniProt 19608861
K579 Ubiquitination PhosphoSitePlus
K584 Acetylation PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
Y598 Phosphorylation PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
T614 Phosphorylation PhosphoSitePlus
C618 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 19651622, 20166139, 10446213, ...20058876, 20230923
S5 Phosphorylation P17612 (PRKACA) HPRD 19651622, 20166139, 10446213, ...20058876, 20230923
Y28 Phosphorylation HPRD 18083107
Y124 Phosphorylation HPRD 15592455
S243 Phosphorylation HPRD 20068231
S257 Phosphorylation HPRD 19651622, 20058876, 20230923
Y276 Phosphorylation HPRD 18083107
S537 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 F7 Biomuta DOID:4159 / skin cancer [ cosmic ]
S7 P7 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic, icgc ]
Y28 C28 Biomuta DOID:3571 / liver cancer [ cosmic ]
S30 I30 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S30 G30 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K39 R39 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y48 H48 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K88 N88 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S110 C110 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S243 R243 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S243 G243 Biomuta DOID:363 / uterine cancer [ icgc ]
K263 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S265 T265 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y276 * Biomuta DOID:1324 / lung cancer [ cosmic ]
C283 Y283 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K294 R294 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y299 F299 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T399 A399 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y430 C430 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K468 N468 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S474 F474 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K542 N542 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S547 G547 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y598 C598 Biomuta DOID:4159 / skin cancer [ cosmic ]