Protein Information

Cytoscape View


UniProt AC / UniProt ID P13674 / P4HA1_HUMAN
Protein Name Prolyl 4-hydroxylase subunit alpha-1 precursor
Gene Name Name: P4HA1
Synonyms:P4HA;
Organism Homo sapiens (Human)

PRO ID PR:P13674
DAG View
PRO Name prolyl 4-hydroxylase subunit alpha-1 (human)
Definition A prolyl 4-hydroxylase subunit alpha-1 that is encoded in the genome of human.
Short Label hP4HA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13674 (P4HA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T40 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
Y45 Phosphorylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
N113 N-Glycosylation GlyGen   UniProt 23090970, 29741879, 19159218, ...24190977
K132 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
N259 N-Glycosylation GlyGen 24190977
Y282 Phosphorylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
K382 Acetylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K372 Ubiquitination PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S41 F41 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:11054 / urinary bladder cancer [ icgc ]
K72 Q72 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]