Protein Information

Cytoscape View


UniProt AC / UniProt ID P13612 / ITA4_HUMAN
Protein Name Integrin alpha-4 precursor
Gene Name Name: ITGA4
Synonyms:CD49D;
Organism Homo sapiens (Human)

PRO ID PR:P13612
DAG View
PRO Name integrin alpha-4 (human)
Definition An integrin alpha-4 that is encoded in the genome of human.
Short Label hITGA4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13612 (ITGA4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N75 N-Glycosylation GlyGen 24190977
N79 N-Glycosylation GlyGen 24190977
K95 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
N138 N-Glycosylation GlyGen 24190977
K149 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
N480 N-Glycosylation GlyGen   UniProt 19349973, 24190977
N518 N-Glycosylation GlyGen   UniProt 19349973
N538 N-Glycosylation GlyGen   UniProt 19349973
K590 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
N626 N-Glycosylation GlyGen 24190977
S634 Phosphorylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
N645 N-Glycosylation GlyGen   UniProt 19349973, 24190977
S734 Phosphorylation PhosphoSitePlus
K760 Ubiquitination PhosphoSitePlus
K771 Ubiquitination PhosphoSitePlus
K867 Ubiquitination PhosphoSitePlus
K906 Ubiquitination PhosphoSitePlus
S924 Phosphorylation PhosphoSitePlus
K1010 Ubiquitination PhosphoSitePlus
S1011 Phosphorylation PhosphoSitePlus
S1021 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   Signor   UniProt 11533025, 19690332, 24275569, ...18583710
S1023 Phosphorylation PhosphoSitePlus
Y1024 Phosphorylation PhosphoSitePlus
S1027 Phosphorylation phospho.ELM 11533025
K1028 Ubiquitination PhosphoSitePlus
S1029 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1021 Phosphorylation P17612 (PRKACA) HPRD 11533025, 20166139, 18578522, ...18707149


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N79 K79 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K116 E116 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K116 N116 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K116 * Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K236 N236 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K280 N280 Biomuta DOID:3571 / liver cancer [ icgc ]
K363 N363 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K606 N606 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
N645 S645 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S1021 R1021 Biomuta DOID:263 / kidney cancer [ tcga ]
Y1024 N1024 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S1027 R1027 Biomuta DOID:3571 / liver cancer [ tcga ]
S1029 R1029 Biomuta DOID:1324 / lung cancer [ tcga ]
S1029 G1029 Biomuta DOID:3571 / liver cancer [ tcga ]