iPTMnet Report for P13569 (CFTR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P13569 / CFTR_HUMAN
Protein Name Cystic fibrosis transmembrane conductance regulator
Gene Name Name: CFTR
Synonyms:ABCC7;
Organism Homo sapiens (Human)

PRO ID PR:P13569
DAG View
PRO Name cystic fibrosis transmembrane conductance regulator (human)
Definition A cystic fibrosis transmembrane conductance regulator that is encoded in the genome of human.
Short Label hCFTR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13569 (CFTR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S45 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 18597485, 28003367, 21930781
S422 Phosphorylation P68400 (CSNK2A1) Signor 21930781
S427 Phosphorylation PhosphoSitePlus
K447 Sumoylation PhosphoSitePlus
S511 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 18597485, 24178769, 17289674, ...21930781
S511 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 21930781, 17289674
Y512 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P+   RLIMS-P 21807898, 24178769, 21930781
Y512 Phosphorylation P07948 (LYN) RLIMS-P+ 24178769
Y512 Phosphorylation P43405 (SYK) neXtProt   PhosphoSitePlus 21807898, 21930781
Y515 Phosphorylation PhosphoSitePlus   RLIMS-P+ 24178769
Y515 Phosphorylation P07948 (LYN) RLIMS-P+ 24178769
Y517 Phosphorylation RLIMS-P+ 24178769
Y517 Phosphorylation P07948 (LYN) RLIMS-P+ 24178769
S549 Phosphorylation PhosphoSitePlus   UniProt 20068231
S573 Phosphorylation IEDB 32387766
T582 Phosphorylation PhosphoSitePlus   RLIMS-P 12588899
T604 Phosphorylation PhosphoSitePlus   RLIMS-P 12588899
S605 Phosphorylation PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus   RLIMS-P 12588899
S660 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22119790, 9385646, 25330774, ...14602047, 7690753, 1377674, 10581361, 1716180
S660 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 1716180
S660 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 14602047, 9385646, 1716180
S660 Phosphorylation Q13976 (PRKG1) Signor 1377674, 10581361
S670 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 18597485, 25330774
T682 Phosphorylation PhosphoSitePlus   RLIMS-P 12588899
S686 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 22119790, 12588899, 1377674
K688 Ubiquitination UniProt 22119790
K698 Methylation PhosphoSitePlus
S700 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19328185, 30296824, 22119790, ...9385646, 25330774, 14602047, 1377674
S700 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 14602047, 19328185, 9385646
S707 Phosphorylation PhosphoSitePlus   RLIMS-P 12588899
S712 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 14602047, 25330774, 9385646, ...22119790
S712 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 14602047, 9385646
T717 Phosphorylation UniProt 22119790
S737 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19328185, 24727471, 22119790, ...9385646, 25330774, 14602047, 19095655, 1377674, 35353541, 7690753, 16887929, 1716180, 19419994
S737 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 1716180
S737 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 14602047, 19328185, 19095655, ...9385646, 1716180
S737 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus   Signor 19095655, 19419994
S737 Phosphorylation Q8IWU2 (LMTK2) neXtProt   PhosphoSitePlus 16887929, 24727471
S753 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 30296824, 9385646, 25330774, ...14602047, 7530719
S753 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 7530719, 9385646
S768 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19328185, 30296824, 9385646, ...20952391, 14602047, 19095655, 1377674, 25330774, 19419994, 15657296
S768 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 14602047, 19328185, 19095655, ...15657296
S768 Phosphorylation Q13131 (PRKAA1) neXtProt   PhosphoSitePlus   Signor 19095655, 19419994
T774 Phosphorylation PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus
S790 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12588899, 1377674
T791 Phosphorylation RLIMS-P 12588899
S795 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22119790, 9385646, 25330774, ...14602047, 7690753, 1377674, 10581361, 1716180
S795 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 1716180
S795 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 14602047, 9385646, 1716180
S795 Phosphorylation Q13976 (PRKG1) Signor 1377674, 10581361
S809 Phosphorylation PhosphoSitePlus
S813 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19328185, 21455600, 9385646, ...25330774, 14602047, 7690753, 1377674, 10581361, 1716180
S813 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 1716180
S813 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 14602047, 19328185, 9385646, ...1716180
S813 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 21455600
S813 Phosphorylation Q13976 (PRKG1) Signor 1377674, 10581361
T816 Phosphorylation PhosphoSitePlus
N894 N-Glycosylation GlyGen   UniProt 20008117, 7518437
N900 N-Glycosylation GlyGen   UniProt 20008117, 7518437
Y1014 Phosphorylation PhosphoSitePlus
T1019 Phosphorylation PhosphoSitePlus
S1045 Phosphorylation PhosphoSitePlus
T1176 Phosphorylation PhosphoSitePlus
S1362 Phosphorylation PhosphoSitePlus
Y1424 Phosphorylation PhosphoSitePlus
S1444 Phosphorylation UniProt 22119790
S1455 Phosphorylation PhosphoSitePlus
S1456 Phosphorylation PhosphoSitePlus   UniProt 22119790
T1471 Phosphorylation PhosphoSitePlus   RLIMS-P+   Signor 21930781, 24058532
T1471 Phosphorylation P68400 (CSNK2A1) Signor 21930781
T1471 Phosphorylation PR:000037188 (casein kinase II (mouse)) RLIMS-P+ 24058532
Site PTM Type PTM Enzyme Score Source PMID
T291 Phosphorylation HPRD 20068231
S549 Phosphorylation HPRD 20068231
S660 Phosphorylation HPRD 1377674
S660 Phosphorylation Q13976 (PRKG1) HPRD 1377674
S686 Phosphorylation HPRD   PRO 1377674
S686 Phosphorylation P17252 (PRKCA) HPRD 1377674
S700 Phosphorylation HPRD 1377674
S700 Phosphorylation P17612 (PRKACA) HPRD 1377674
S700 Phosphorylation Q13976 (PRKG1) HPRD 1377674
S737 Phosphorylation HPRD   PRO 14602047, 1716180, 1377674
S737 Phosphorylation P17612 (PRKACA) HPRD 1377674
S737 Phosphorylation Q13976 (PRKG1) HPRD 1377674
S768 Phosphorylation HPRD   PRO 14602047, 1716180, 1377674
S768 Phosphorylation P17612 (PRKACA) HPRD 1377674
S768 Phosphorylation Q13976 (PRKG1) HPRD 1377674
S790 Phosphorylation HPRD   PRO 1377674
S790 Phosphorylation P17252 (PRKCA) HPRD 1377674
S795 Phosphorylation HPRD   PRO 14602047, 1716180, 1377674
S795 Phosphorylation P17612 (PRKACA) HPRD 1377674
S795 Phosphorylation Q13976 (PRKG1) HPRD 1377674
S813 Phosphorylation HPRD   PRO 14602047, 1716180, 1377674
S813 Phosphorylation P17612 (PRKACA) HPRD 1377674
S813 Phosphorylation Q13976 (PRKG1) HPRD 1377674
N894 N-Glycosylation PRO 7518437
N900 N-Glycosylation PRO 7518437
T1176 Phosphorylation HPRD 19413330
S1362 Phosphorylation HPRD 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046699 (hCFTR/UbiqLys+) ub PRO
PR:000036594 (hCFTR/iso:1/Phos:1) pS737,pS768,pS795,pS813 PRO 1377674, 14602047, 1716180
PR:000036595 (hCFTR/iso:1/Phos:2) pS686,pS737,pS768,pS790,pS795,pS813 PRO 1377674


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S45 Y45 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S422 F422 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S422 P422 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S511 F511 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y512 C512 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S660 L660 Biomuta DOID:4159 / skin cancer [ cosmic ]
S660 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S670 A670 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K698 N698 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K698 E698 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S700 F700 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S700 Y700 Biomuta DOID:1319 / brain cancer [ cosmic ]
S707 Y707 Biomuta DOID:363 / uterine cancer [ icgc ]
S712 F712 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T774 I774 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S809 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T1019 A1019 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1362 N1362 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:1324 / lung cancer [ cosmic ]
Y1424 H1424 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1444 F1444 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1456 I1456 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]