iPTMnet Report for P13073 (COX4I1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P13073 / COX41_HUMAN
Protein Name Cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor
Gene Name Name: COX4I1
Synonyms:COX4;
Organism Homo sapiens (Human)

PRO ID PR:P13073
DAG View
PRO Name cytochrome c oxidase subunit 4 isoform 1, mitochondrial (human)
Definition A cytochrome c oxidase subunit 4 isoform 1, mitochondrial that is encoded in the genome of human.
Short Label hCOX4I1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P13073 (COX4I1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K12 Methylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
Y38 Phosphorylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus   UniProt 19608861
K53 Ubiquitination PhosphoSitePlus
K60 Acetylation PhosphoSitePlus   UniProt 19608861
K60 Ubiquitination PhosphoSitePlus
K63 Methylation PhosphoSitePlus
K67 Acetylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S89 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y124 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
S158 Phosphorylation HPRD   PhosphoSitePlus 20068231
K159 Acetylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K164 Acetylation PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K168 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S34 L34 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
K53 N53 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y124 C124 Biomuta DOID:363 / uterine cancer [ icgc ]
K135 E135 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]