iPTMnet Report for P12955 (PEPD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P12955 / PEPD_HUMAN
Protein Name Xaa-Pro dipeptidase
Gene Name Name: PEPD
Synonyms:PRD;
Organism Homo sapiens (Human)

PRO ID PR:P12955
DAG View
PRO Name Xaa-Pro dipeptidase (human)
Definition An Xaa-Pro dipeptidase that is encoded in the genome of human.
Short Label hPEPD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12955 (PEPD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22223895
K17 Acetylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus   UniProt 24275569
T188 Phosphorylation phospho.ELM   PhosphoSitePlus 16097034
R196 Methylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
T487 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S490 Phosphorylation PhosphoSitePlus
K493 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T487 Phosphorylation HPRD 15302935
Site PTM Type PTM Enzyme Score Source PMID
S78 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K17 N17 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K110 N110 Biomuta DOID:1324 / lung cancer [ cosmic ]
S113 F113 Biomuta DOID:4159 / skin cancer [ cosmic ]
K120 R120 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T188 A188 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R196 C196 Biomuta DOID:263 / kidney cancer [ cosmic ]
S490 C490 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]