iPTMnet Report for P12814 (ACTN1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P12814 / ACTN1_HUMAN
Protein Name Alpha-actinin-1
Gene Name Name: ACTN1
Organism Homo sapiens (Human)

PRO ID PR:P12814
DAG View
PRO Name alpha-actinin-1 (human)
Definition An alpha-actinin-1 that is encoded in the genome of human.
Short Label hACTN1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P12814 (ACTN1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 21406692
Y4 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus   UniProt 21406692
T9 Phosphorylation PhosphoSitePlus
Y12 Phosphorylation A0A059VC25 (FAK) , Q05397 (PTK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23454549, 11369769, 17898132
K31 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
T50 Phosphorylation phospho.ELM   PhosphoSitePlus 16097034
S73 Phosphorylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
K95 Acetylation PhosphoSitePlus   UniProt 19608861
S102 Phosphorylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
S140 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T144 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
C154 S-Nitrosylation dbSNO 25040305
K162 Ubiquitination PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K195 Acetylation PhosphoSitePlus   UniProt 19608861
K195 Ubiquitination PhosphoSitePlus
K198 Acetylation PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
R261 Methylation PhosphoSitePlus
Y279 Phosphorylation PhosphoSitePlus
S284 Phosphorylation PhosphoSitePlus
R291 Methylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
C332 S-Nitrosylation dbSNO 19483679, 20140087, 19366988, ...18335467
T340 Phosphorylation PhosphoSitePlus
T343 Phosphorylation PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
K398 Acetylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
K413 Acetylation PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
Y422 Phosphorylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
Y467 Phosphorylation PhosphoSitePlus
S471 Phosphorylation PhosphoSitePlus   UniProt 24275569
K478 Ubiquitination PhosphoSitePlus
C480 S-Nitrosylation dbSNO 20140087
K492 Acetylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
Y511 Phosphorylation PhosphoSitePlus
Y514 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
Y674 Phosphorylation PhosphoSitePlus
K676 Acetylation PhosphoSitePlus   UniProt 19608861
K676 Ubiquitination PhosphoSitePlus
S677 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y681 Phosphorylation PhosphoSitePlus
K684 Ubiquitination PhosphoSitePlus
Y708 Phosphorylation PhosphoSitePlus
T722 Phosphorylation PhosphoSitePlus
T727 Phosphorylation PhosphoSitePlus
T737 Phosphorylation PhosphoSitePlus
S744 Phosphorylation PhosphoSitePlus
S763 Phosphorylation PhosphoSitePlus
T765 Phosphorylation PhosphoSitePlus
S797 Phosphorylation PhosphoSitePlus
T820 Phosphorylation PhosphoSitePlus
T823 Phosphorylation PhosphoSitePlus
T825 Phosphorylation PhosphoSitePlus
S832 Phosphorylation PhosphoSitePlus
Y842 Phosphorylation PhosphoSitePlus
T844 Phosphorylation PhosphoSitePlus
Y859 Phosphorylation PhosphoSitePlus
Y887 Phosphorylation PhosphoSitePlus
S890 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y12 Phosphorylation Q05397 (PTK2) HPRD   PRO 11369769, 16291744
T50 Phosphorylation HPRD 18452278
S140 Phosphorylation HPRD 20166139, 18669648, 19664994, ...17081983, 19664995
Y193 Phosphorylation HPRD 18083107


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025712 (hACTN1/iso:1/Phos:1) pY12 PRO 16291744


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025712 (hACTN1/iso:1/Phos:1) Interaction PR:P12931 (hSRC) PRO 16291744
PR:000025712 (hACTN1/iso:1/Phos:1) Interaction PR:P18031 (hPTPN1) PRO 16291744